N-chloro-1-phenylethanamine

Base Information

• Chemical Name: N-chloro-1-phenylethanamine
• CAS No.: 35474-20-5
• Molecular Formula: C8H10ClN
• Molecular Weight: 155.627
• Mol file: 35474-20-5.mol

Synonyms:NSC224227;

Chemical Property of N-chloro-1-phenylethanamine

Chemical Property:

• Vapor Pressure: 0.134mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 217.3 °C at 760 mmHg
• Flash Point: 85.2 °C
• Density: 1.086 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-chloro-1-phenylethanamine

There total 2 articles about N-chloro-1-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-methylbenzylamine (618-36-0) → N-chloro-α-methylbenzylamine (35474-20-5)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/ol4023886

Reference yield:

N-chloro-succinimide (128-09-6) + rac-methylbenzylamine (618-36-0) → N-chloro-α-methylbenzylamine (35474-20-5)

Guidance literature:

In tetrahydrofuran; for 0.166667h; Inert atmosphere; Sealed tube;

DOI:10.1039/c3cc42937g

Reference yield: 95.0%

N-chloro-α-methylbenzylamine (35474-20-5) + 4-methoxy-benzaldehyde (123-11-5) → N-(p-methoxybenzoyl)-α-methylbenzyl amine (68162-84-5)

Guidance literature:

With tert.-butylhydroperoxide; 2,2'-azobis(isobutyronitrile); In water; acetonitrile; at 80 ℃; for 24h; Mechanism;

DOI:10.1039/c3gc41548a

upstream raw materials:

N-chloro-succinimide

rac-methylbenzylamine

Downstream raw materials:

C₁₇H₁₉N₃O₃

N-(1-phenylethyl)benzamide

(±)-N-(m-chlorobenzoyl)-α-methylbenzylamine

N-(p-methoxybenzoyl)-α-methylbenzyl amine

Refernces

• 1、 Jolley, Katherine E.,Chapman, Michael R.,John Blacker. "A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines". supporting information. p. 2220 - 2228. Retrieved 2018/09/04.
• 2、 Ng, Ka-Ho,Zhou, Zhongyuan,Yu, Wing-Yiu. "[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines". supporting information. p. 7031 - 7033. Retrieved 2013/09/02.