PENTAGLYCINE

Base Information

• Chemical Name: PENTAGLYCINE
• CAS No.: 7093-67-6
• Molecular Formula: C10H17N5O6
• Molecular Weight: 303.275
• Mol file: 7093-67-6.mol

Synonyms:N-(N-(N-(N-Glycylglycyl)glycyl)glycyl)glycine;Gly_Gly_Gly_Gly_Gly;2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid;Gly-Gly-Gly-Gly;Gly-Gly-Gly-Gly-Gly-OH;glycylglycylglycylglycylglycine;H-(Gly)5-OH;

Chemical Property of PENTAGLYCINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >300 °C (decomp)
• Boiling Point: 942.3°Cat760mmHg
• PKA: 3.32±0.10(Predicted)
• Flash Point: 523.7°C
• PSA: 179.72000
• Density: 1.406g/cm³
• LogP: -2.24160
• Storage Temp.: −20°C
• Solubility.: Aqueous Acid (Slightly), Water (Slightly, Heated)

Purity/Quality:

99%+, ^*data from raw suppliers

Gly-Gly-Gly-Gly-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Pentaglycine could be a useful tumor necrosis factor receptor 2 agonist.

Technology Process of PENTAGLYCINE

There total 19 articles about PENTAGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine (56-40-6,18875-39-3,25718-94-9) → Glycine anhydride (106-57-0) + glycine-glycine-glycine (556-33-2) + tetraglycine (637-84-3) + pentaglycine (7093-67-6) + hexaglycine (3887-13-6) + glycylglycine (556-50-3)

Guidance literature:

With titanium(IV) oxide; at 40 ℃; Milling;

DOI:10.1002/anie.202100806

Reference yield:

Glycine anhydride (106-57-0) → glycine-glycine-glycine (556-33-2) + tetraglycine (637-84-3) + pentaglycine (7093-67-6) + hexaglycine (3887-13-6) + glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine (18861-82-0) + glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine (38416-68-1) + glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine (65042-71-9)

Guidance literature:

With titanium(IV) oxide; at 130 ℃; Milling;

DOI:10.1002/anie.202100806

Reference yield:

glycine (56-40-6,18875-39-3,25718-94-9) → Glycine anhydride (106-57-0) + glycine-glycine-glycine (556-33-2) + tetraglycine (637-84-3) + pentaglycine (7093-67-6) + hexaglycine (3887-13-6) + glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine (18861-82-0) + glycylglycine (556-50-3)

Guidance literature:

With titanium(IV) oxide; at 20 ℃; Milling;

DOI:10.1002/anie.202100806

upstream raw materials:

N-chloroacetyl-glycyl=>glycyl=>glycyl=>glycine

glycine

H-(Gly)4-OH hydrochloride

glycine-glycine-glycine

Downstream raw materials:

glycine

p-[N-(4-pentaglycyl-2,3-dioxocyclobut-1-enyl)amino]phenyl α-D-mannopyranoside

4-nitro-phenol

N-acetylglycine pentamer

Refernces

• 1、 Gorokhova,Chinarev,Tuzikov,Tsygankova,Bovin. "Spontaneous and promoted association of linear oligoglycines". . p. 420 - 428. Retrieved 2008/02/10.