Corynantheidol

Base Information

• Chemical Name: Corynantheidol
• CAS No.: 483-27-2
• Molecular Weight: 298.4225
• Nikkaji Number: J376.987I
• Wikidata: Q105138350
• Mol file: 483-27-2.mol

Synonyms:corynantheidol

Chemical Property of Corynantheidol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 480.248°C at 760 mmHg
• Flash Point: 244.246°C
• Density: 1.187g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 298.204513457
• Heavy Atom Count: 22
• Complexity: 388

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1CN2CCC3=C(C2CC1CCO)NC4=CC=CC=C34
• Isomeric SMILES: CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1CCO)NC4=CC=CC=C34

Technology Process of Corynantheidol

There total 236 articles about Corynantheidol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C25H40N2OSi → (+/-)-corynantheidol (483-27-2,2270-72-6,4695-99-2,4697-70-5,15218-28-7,15218-29-8,23107-07-5,23107-08-6,55903-44-1,141846-19-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 20 ℃; for 12h;

DOI:10.1021/jo101775n

Reference yield: 90.0%

C25H40N2OSi → (+/-)-dihydrocorynantheol (483-27-2,2270-72-6,4695-99-2,4697-70-5,15218-28-7,15218-29-8,23107-07-5,23107-08-6,55903-44-1,141846-19-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/jo101775n

Reference yield: 71.0%

Acetic acid 2-((2S,3S,12bS)-3-ethyl-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl)-ethyl ester → (+/-)-3-epi-dihydrocorynantheol (483-27-2,2270-72-6,4695-99-2,4697-70-5,15218-28-7,15218-29-8,23107-07-5,23107-08-6,55903-44-1,141846-19-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Ambient temperature;

upstream raw materials:

2-((2R,12bS,E)-3-ethylidene-1,2,3,4,6,7,12,12b-octahydroindolo-[2,3-a]quinolizin-2-yl)ethanol

N²-(Methoxymethyl)corynantheidol

corynan-17-oic acid methyl ester

diphenylthio-2,2' formyl-4 butyrate de methyle

Downstream raw materials:

(+/-)-dihydrocorynantheol

Refernces

• 1、 Kobayashi, Yuichi,Yagi, Kaori,Kaneko, Yuki. "Convenient synthesis of the key intermediate for dihydrocorynantheol and protoemetinol from the monoacetate of 4-cyclopentene-1,3-diol". . p. 1541 - 1548. Retrieved 2011/05/05.
• 2、 Li, Yanwu,Kobayashi, Toyoharu,Katsumura, Shigeo. "Synthesis of indole alkaloid (-)-corynantheidol and formal synthesis of (-)-corynantheidine via one-pot asymmetric azaelectrocyclization". scheme or table. p. 4482 - 4484. Retrieved 2009/12/03.