2-methyl-N~1~-phenylpropane-1,2-diamine

Base Information

• Chemical Name: 2-methyl-N~1~-phenylpropane-1,2-diamine
• CAS No.: 5462-03-3
• Molecular Formula: C10H16N2
• Molecular Weight: 164.2474
• Mol file: 5462-03-3.mol

Synonyms:

Chemical Property of 2-methyl-N~1~-phenylpropane-1,2-diamine

Chemical Property:

• Vapor Pressure: 0.00251mmHg at 25°C
• Boiling Point: 287.3°Cat760mmHg
• Flash Point: 148.1°C
• Density: 1.013g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-N~1~-phenylpropane-1,2-diamine

There total 4 articles about 2-methyl-N~1~-phenylpropane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Amino-2-methyl-1-propanol (124-68-5) + aniline (62-53-3) → 2-methyl-N1-phenylpropane-1,2-diamine (5462-03-3)

Guidance literature:

With [RuCl(N,N-dimethyl-1-[6-(4'-methylphenyl)pyridin-2-yl]methaneamine(-H))(dppb)]; potassium tert-butylate; In tetrahydrofuran; toluene; at 110 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol3001969

Reference yield:

aniline (62-53-3) → 2-methyl-N1-phenylpropane-1,2-diamine (5462-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; water; trimethyl-benzyl-ammonium hydroxide

2: Raney nickel; methanol / 51485.6 Torr / Hydrogenation

With methanol; water; N-benzyl-trimethylammonium hydroxide; nickel;

DOI:10.1021/ja01205a006

Reference yield:

2,2-dimethylaziridine (2658-24-4) + aniline (62-53-3) → 1,1-dimethyl-N1-phenyl-ethanediyldiamine (68173-00-2) + 2-methyl-N1-phenylpropane-1,2-diamine (5462-03-3)

Guidance literature:

With ammonium chloride;

DOI:10.1021/ja01181a053

upstream raw materials:

2,2-dimethylaziridine

aniline

2-Amino-2-methyl-1-propanol

2-bromo-2-methyl-N-phenylpropanamide

Downstream raw materials:

3,3,5,5-tetramethyl-1-phenylpiperazin-2-one

Refernces

• 1、 Ishida, Syo,Takeuchi, Kentaro,Taniyama, Nobuhiro,Sunada, Yusuke,Nishikata, Takashi. "Copper-Catalyzed Amination of Congested and Functionalized α-Bromocarboxamides with either Amines or Ammonia at Room Temperature". . p. 11610 - 11614. Retrieved 2017/09/11.
• 2、 CLAPP. "Reactions of ethylenimines; with ammonia and amines.". . p. 184 - 186. Retrieved 2007/10/04.