Aminoguanidine hydrochloride

Base Information

• Chemical Name: Aminoguanidine hydrochloride
• CAS No.: 16139-18-7
• Molecular Formula: CH6N4.xClH
• Molecular Weight: 110.54600
• European Community (EC) Number: 240-295-5,217-707-7
• NSC Number: 760398
• UNII: A2Z7G2RGAH
• DSSTox Substance ID: DTXSID9044405
• Wikidata: Q27095586
• NCI Thesaurus Code: C76661
• ChEMBL ID: CHEMBL1256292
• Mol file: 16139-18-7.mol

Synonyms:aminoguanidine;aminoguanidine sulfate;hydrazinecarboximidamide;monoaminoguanidine;pimagedine;pimagedine hydrochloride

Chemical Property of Aminoguanidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0116mmHg at 25°C
• Melting Point: 162-166°C(lit.)
• Boiling Point: 261.4oC at 760 mmHg
• Flash Point: 111.9oC
• PSA: 87.92000
• LogP: 1.03640
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 110.0359239
• Heavy Atom Count: 6
• Complexity: 41.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

Aminoguanidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=NN)(N)N.Cl
• Uses: Inhibitor (advanced glycosylation end-product formation).

Technology Process of Aminoguanidine hydrochloride

There total 6 articles about Aminoguanidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

→ 1-aminoguanidine hydrochloride (1937-19-5,16139-18-7) + 6-Chloronicotinic acid 2-amidinohydrazide (168893-67-2)

Guidance literature:

Reference yield:

aminoguanidine bicarbonate (2582-30-1) → 1-aminoguanidine hydrochloride (1937-19-5,16139-18-7)

Guidance literature:

With hydrogenchloride; In ethanol;

DOI:10.1021/jm061077m

Reference yield:

CYANAMID (420-04-2) → 1-aminoguanidine hydrochloride (1937-19-5,16139-18-7)

Guidance literature:

With ethanol;

upstream raw materials:

ethanol

CYANAMID

aminoguanidine bicarbonate

acetic acid 2-guanylhydrazide hydrochloride

Downstream raw materials:

phenacylidenamino-guanidine

1H,1′H-[3,3′-bi-1,2,4-triazole]-5,5′-diamine

4-Cyclohexyl-1-guanyl-thiosemicarbazid

N-Guanidino-N'-(4-brom-phenyl)-thioharnstoff

Refernces

• 1、 Corona-Martinez, David O.,Taran, Olga,Yatsimirsky, Anatoly K.. "Mechanism of general acid-base catalysis in transesterification of an RNA model phosphodiester studied with strongly basic catalysts". . p. 873 - 880. Retrieved 2010.
• 2、 Tarasova,Chernyshev,Chernysheva,Abagyan. "Thermodynamic and kinetic aspects of a single-reactor synthesis of 5-amino-3-methyl-1,2,4-triazole hydrochloride from aminoguanidine and acetic acid". experimental part. p. 400 - 406. Retrieved 2011/08/04.