Trimethylsilyl acetate

Base Information

• Chemical Name: Trimethylsilyl acetate
• CAS No.: 2754-27-0
• Molecular Formula: C5H12O2Si
• Molecular Weight: 132.235
• Hs Code.: 29319090
• European Community (EC) Number: 220-404-2
• NSC Number: 96780
• UNII: LXX47M44WG
• DSSTox Substance ID: DTXSID90883723
• Nikkaji Number: J299.214K
• Wikidata: Q72514427
• Mol file: 2754-27-0.mol

Synonyms:Trimethylsilyl acetate;2754-27-0;Acetoxytrimethylsilane;Trimethylacetoxysilane;Silanol, 1,1,1-trimethyl-, 1-acetate;Silanol, trimethyl-, acetate;(Acetato)trimethylsilane;Acetic Acid Trimethylsilyl Ester;TRIMETHYLSILYLACETATE;NSC 96780;Acetic acid, TMS derivative;LXX47M44WG;EINECS 220-404-2;NSC-96780;TMSOAc;o-trimethylsilylacetate;Acetyloxytrimethylsilane;Trimethylsilyl acetate;trimethylsilyl ethanoate;CH3COOSi(CH3)3;UNII-LXX47M44WG;NCIOpen2_001849;Trimethylsilyl acetate, 97%;SCHEMBL338658;DTXSID90883723;CAA75427;NSC96780;MFCD00008695;AKOS015892883;CS-W011087;FS-3997;BP-21426;FT-0653703;E75967;S00009;A819111;Ethyl (2E)-2-cyano-3-(1H-indolyl-3-yl)acrylate;J-802297

Chemical Property of Trimethylsilyl acetate

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 35 mm Hg ( 30 °C)
• Melting Point: -32 °C(lit.)
• Refractive Index: n20/D 1.388(lit.)
• Boiling Point: 107.5 °C at 760 mmHg
• Flash Point: 6 °C
• PSA: 26.30000
• Density: 0.879 g/cm³
• LogP: 1.38440
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Water Solubility.: reacts
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 132.060656156
• Heavy Atom Count: 8
• Complexity: 93.1

Purity/Quality:

99% ^*data from raw suppliers

Trimethylsilyl Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 11
• Safety Statements: 16-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)O[Si](C)(C)C

Technology Process of Trimethylsilyl acetate

There total 82 articles about Trimethylsilyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,1,1,2,2,2-hexamethyldisilane (1450-14-2) + Allyl acetate (591-87-7) → propene (187737-37-7,13987-01-4,15220-87-8,9003-07-0,676-63-1,25085-53-4) + trimethylsilyl acetate (2754-27-0) + allyl-trimethyl-silane (762-72-1) + (E)-trimethyl(prop-1-en-1-yl)silane (4964-03-8)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 180 ℃; for 2h; high pressure, under nitrogen;

DOI:10.1246/bcsj.57.607

Reference yield: 99.0%

ethyl trimethylsilyl ether (1825-62-3) + acetic anhydride (108-24-7) → trimethylsilyl acetate (2754-27-0)

Guidance literature:

With iron(II) bromide; at 25 ℃; for 0.0833333h; Reagent/catalyst; Temperature;

Reference yield: 99.0%

Trimethylsilanol (1066-40-6) + acetic anhydride (108-24-7) → trimethylsilyl acetate (2754-27-0)

Guidance literature:

With iron perchlorate hexahydrate; at 25 ℃; for 0.166667h; Reagent/catalyst; Temperature;

upstream raw materials:

chloro-trimethyl-silane

zinc diacetate

sodium acetate

trimethylsilyl bromide

Downstream raw materials:

Bis(trimethylsilyl) ketene acetal

α-trimethylsilyl trimethylsilylacetic ester

1,3,4,6-tetra-O-acetyl-2-O-trimethylsilyl-β-D-galactopyranose

β-D-galactose peracetate

Refernces

• 1、 Peddle,G.J.D.,Walsingham,R.W.. "". . p. 2154 - 2155. Retrieved 1969.
• 2、 Jiang, Xin-Dong,Zhang, Jian,Furuyama, Taniyuki,Zhao, Weili. "Development of mono- and Di-AcO substituted BODIPYs on the boron center". . p. 248 - 251. Retrieved 2012.
• 3、 Aprile, Antonino,Iversen, Kalon J.,Wilson, David J. D.,Dutton, Jason L.. "Te(II)/Te(IV) Mediated C-N Bond Formation on 2,5-Diphenyltellurophene and a Reassignment of the Product from the Reaction of PhI(OAc)2 with 2 TMS-OTf". . p. 4934 - 4939. Retrieved 2015.
• 4、 Chen, Jyun-Siao,Huang, Po-Hsun,Hsieh, Ya-Chi,Liu, Jen-Wei,Hsu, Hsiao-Lin,Zhang, Kai-Min,Wu, Ren-Tsung,Chang, Ting-Shuo,Liu, Yu-Hao,Wu, Hsin-Ru,Luo, Shun-Yuan. "Trimethylsilyl Esters as Novel Dual-Purpose Protecting Reagents". supporting information. p. 754 - 762. Retrieved 2021/12/02.
• 5、 -. "Method for Producing Acyloxysilanes, Acyloxysilanes Obtained Thereby, and Use of Same". Paragraph 0130; 0131. . Retrieved 2018/03/25.