5-ACETYL-6-METHYL-2(1H)-PYRIDINONE

Base Information

• Chemical Name: 5-ACETYL-6-METHYL-2(1H)-PYRIDINONE
• CAS No.: 5220-65-5
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Hs Code.: 2933399090
• Mol file: 5220-65-5.mol

Synonyms:2(1H)-Pyridone,5-acetyl-6-methyl- (7CI); Ketone, 6-hydroxy-2-methyl-3-pyridyl methyl (8CI);5-Acetyl-6-methyl-2(1H)-pyridinone; SF 36

Chemical Property of 5-ACETYL-6-METHYL-2(1H)-PYRIDINONE

Chemical Property:

• Vapor Pressure: 4.62E-05mmHg at 25°C
• Melting Point: 203-205°
• Boiling Point: 349.7°Cat760mmHg
• Flash Point: 168.5°C
• PSA: 49.93000
• Density: 1.138g/cm³
• LogP: 0.88590

Purity/Quality:

98%min ^*data from raw suppliers

5-Acetyl-6-methyl-2(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Acetyl-6-methyl-2(1H)-pyridinone is a 2-pyridone derivative that has been studied for its potential as an inotropic agent.

Technology Process of 5-ACETYL-6-METHYL-2(1H)-PYRIDINONE

There total 12 articles about 5-ACETYL-6-METHYL-2(1H)-PYRIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxylic acid (88302-06-1) → 5-acetyl-6-methyl-2(1H)-pyridinone (5220-65-5)

Guidance literature:

In various solvent(s); for 3h; Heating;

DOI:10.1248/cpb.39.1556

Reference yield: 62.0%

4-amino-3-penten-2-one (1118-66-7) + propynoic acid methyl ester (922-67-8) → 5-acetyl-6-methyl-2(1H)-pyridinone (5220-65-5)

Guidance literature:

In N,N-dimethyl-formamide; 1) RT, 3.5 h, 2) reflux, 24 h;

Reference yield: 49.0%

5-acetyl-6-methyl-1,2,3,4-tetrahydro-2-pyridinone (13729-69-6) → 5-acetyl-6-methyl-2(1H)-pyridinone (5220-65-5)

Guidance literature:

palladium on activated charcoal; at 250 ℃; for 0.333333h;

upstream raw materials:

5-acetyl-6-methyl-1,2,3,4-tetrahydro-2-pyridinone

5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxylic acid

4-amino-3-penten-2-one

propynoic acid methyl ester

Downstream raw materials:

2-chloro-5-methyl-1,6-naphthyridine

1-[2-(4-benzylpiperidin-1-yl)ethyl]-3-(5-methyl[1,6]naphthyridin-2-yl)urea

2-(4-benzylpiperidin-1-yl)-N-(5-methyl[1,6]naphthyridin-2-yl)acetamide

[2-(4-benzylpiperidin-1-yl)ethyl]-(5-methyl[1,6]naphthyridin-2-yl)amine

Refernces

• 1、 Derbyshire, Paul A.,Hunter, Gordon A.,McNab, Hamish,Monahan, Lilian C.. "3-Hydroxypyrroles and 1H-Pyrrol-3(2H)-ones. Part 13. Reactions of Methoxymethylene Meldrum's Acids with 3-Hydroxypyrroles, with 3-Methoxypyrroles and with other Active Substrates, and Pyrolytic Heterocyclizations of the Products". . p. 2017 - 2026. Retrieved 2007/10/02.
• 2、 Singh, Baldev,Lesher, George Y.. "A Facile and Novel Synthesis of 1,6-Naphthyridin-2(1H)-ones". . p. 2085 - 2091. Retrieved 2007/10/02.