1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE

Base Information

• Chemical Name: 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE
• CAS No.: 273-34-7
• Molecular Formula: C5H4N4
• Molecular Weight: 120.114
• Hs Code.: 2933990090
• Mol file: 273-34-7.mol

Synonyms:1H-1,2,3-Triazolo[4,5-b]pyridine(9CI);1H-v-Triazolo[4,5-b]pyridine (6CI,7CI,8CI);1H-Pyrido[2,3-d]-1,2,3-triazole;1H-Pyrido[2,3-d]-v-triazole;2,7-Diaza-1H-benzimidazole;2,7-Diazabenzimidazole;NSC 64288;[1,2,3]Triazolo[4,5-b]pyridine;2H-[1,2,3]triazolo[4,5-b]pyridine;1H-[1,2,3]Triazolo[4,5-b]pyridine;1H-1,2,3-Triazolo[4,5-b]pyridine;3H-[1,2,3]Triazolo[4,5-b]pyridine;

Chemical Property of 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE

Chemical Property:

• Vapor Pressure: 0.376mmHg at 25°C
• Melting Point: 208 °C (dec.)(lit.)
• Refractive Index: 1.828
• Boiling Point: 303.4 °C at 760 mmHg
• PKA: 3.15±0.20(Predicted)
• Flash Point: 152.9 °C
• PSA: 54.46000
• Density: 1.472 g/cm³
• LogP: 0.35290
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1H-1,2,3-Triazolo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1H-1,2,3-Triazolo[4,5-b]pyridine (1,2,3-Triazolo(5,4-b)pyridine) may be used:as starting reagent in the synthesis of 2,4,8,10-tetranitro-5H-pyrido[3″,2″:4′,5′] [1,2,3] triazolo [1′,2′:1,2] [1,2,3]- triazolo [5,4-b]-pyridin-6-ium inner saltin the pesticide synthesis as an entry to mesoionic heteropentalene derivatives

Technology Process of 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE

There total 10 articles about 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-hydroxy-7-aza-benzotriazole (39968-33-7) → 3H-[1,2,3]triazolo[4,5-b]pyridine (273-34-7)

Guidance literature:

1-hydroxy-7-aza-benzotriazole; With triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

With tetrahydroxydiboron; In acetonitrile; at 50 ℃; for 8h; Reagent/catalyst; Temperature; Solvent; Catalytic behavior;

DOI:10.1002/adsc.201400889

Reference yield: 90.0%

4-aza-1-hydroxybenzotriazole (57115-46-5) → v-triazolo<4,5-b>pyridine (273-34-7)

Guidance literature:

4-aza-1-hydroxybenzotriazole; With triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

With tetrahydroxydiboron; In acetonitrile; at 50 ℃; for 8h;

DOI:10.1002/adsc.201400889

Reference yield: 45.0%

2,3-Diaminopyridine (452-58-4) → 3H-[1,2,3]triazolo[4,5-b]pyridine (273-34-7)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 4 - 50 ℃;

DOI:10.1016/j.ejmech.2010.01.062

upstream raw materials:

2,3-Diaminopyridine

6-chloro-1H-[1,2,3]triazolo[4,5-b]pyridine

5-chloro-2,3-diaminopyridine

2-amino-3-nitropyridine

Downstream raw materials:

2-(2,4-difluorophenyl)-1-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

C₁₆H₁₃F₂N₇O

(4-benzhydrylpiperazin-1-yl)[1,2,3]triazolo[4,5-b]pyridin-1-ylmethanone

C₂₅H₃₀N₄O₃

Refernces

• 1、 Ruefenacht. "-". . p. 1521,1524. Retrieved 1975.
• 2、 Patel, Pallav D.,Patel, Maulik R.,Kocsis, Bela,Kocsis, Erika,Graham, Steven M.,Warren, Andrew R.,Nicholson, Stacia M.,Billack, Blase,Fronczek, Frank R.,Talele, Tanaji T.. "Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles". supporting information; experimental part. p. 2214 - 2222. Retrieved 2010/09/08.