(R)-2-Amino-5-diethylaminopentane

Base Information

• Chemical Name: (R)-2-Amino-5-diethylaminopentane
• CAS No.: 67459-50-1
• Molecular Formula: C8H22N2+2
• Molecular Weight: 158.287
• UNII: Q2BWO1G57G
• Wikidata: Q27286912
• Mol file: 67459-50-1.mol

Synonyms:(R)-2-AMINO-5-DIETHYLAMINOPENTANE;67459-50-1;Novoldiamine, (R)-;(R)-4-Amino-1-(diethylamino)pentane;Q2BWO1G57G;(4R)-1-N,1-N-diethylpentane-1,4-diamine;1,4-Pentanediamine, N1,N1-diethyl-, (4R)-;[(4R)-4-AMINOPENTYL]DIETHYLAMINE;UNII-Q2BWO1G57G;(R)-novoldiamine;SCHEMBL3856709;Q27286912

Chemical Property of (R)-2-Amino-5-diethylaminopentane

Chemical Property:

• Vapor Pressure: 0.872mmHg at 25°C
• Boiling Point: 180.971°C at 760 mmHg
• Flash Point: 60.667°C
• PSA: 29.26000
• LogP: 2.15590
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 158.178298710
• Heavy Atom Count: 11
• Complexity: 79.6

Purity/Quality:

99%min ^*data from raw suppliers

(4R)-N1,N1-DIETHYLPENTANE-1,4-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(CC)CCCC(C)N
• Isomeric SMILES: CCN(CC)CCC[C@@H](C)N

Technology Process of (R)-2-Amino-5-diethylaminopentane

There total 11 articles about (R)-2-Amino-5-diethylaminopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C18H32N2O → (R)-(-)-4-amino-1-(diethylamino)pentane (67459-50-1)

Guidance literature:

With platinum(IV) oxide; hydrogen; In tetrahydrofuran; at 45 ℃; for 6h; Reagent/catalyst;

Reference yield: 78.0%

5-diethylamino-2-pentylamine (140-80-7) → (R)-(-)-4-amino-1-(diethylamino)pentane (67459-50-1)

Guidance literature:

5-diethylamino-2-pentylamine; With S-(+)binaphthol phosphate; In ethanol; isopropyl alcohol; at 20 ℃; Reflux;

With sodium hydroxide; Solvent; Reagent/catalyst; Temperature;

Reference yield:

C13H30N2OS → (R)-(-)-4-amino-1-(diethylamino)pentane (67459-50-1)

Guidance literature:

C₁₃H₃₀N₂OS; With hydrogenchloride; In methanol; water; at 0 - 20 ℃; for 3h;

With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

upstream raw materials:

(S)-2-amino-5-(diethylamino)pentan-1-ol

N,N-diethyl-(S)-glutamine hydrochloride

methyl 3-methoxypropionate

5-diethylamino-2-pentylamine

Downstream raw materials:

(R)-(-)-chloroquine

(R)-chloroquine phosphate

(R)-chloroquine phosphate

5-diethylamino-2-pentylamine

Refernces

• 1、 -. "Optically active chloroquine and hydroxychloroquine and analogues thereof, and preparation method, composition and application of optically active chloroquine and hydroxychloroquine". . . Retrieved 2021/03/11.
• 2、 -. "Application of chiral chloroquine, hydroxychloroquine or salt of the chiral chloroquine and hydroxychloroquine as anti-coronavirus drug target 3CL hydrolase inhibitor for reducing cardiotoxicity". . . Retrieved 2020/11/02.