2-(2-Methyl-1.3-dioxolan-2-yl)acetic acid

Base Information

• Chemical Name: 2-(2-Methyl-1.3-dioxolan-2-yl)acetic acid
• CAS No.: 5735-97-7
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Mol file: 5735-97-7.mol

Synonyms:3,3-ethylenedioxy-butanoic acid;1,3-dioxolane-2-methyl-2-acetic acid;2-(carboxymethyl)-2-methyldioxolane;3-oxobutanoic acid ethylene ketal;3,3-ethylenedioxybutanoic acid;3-(1,3-Dioxolan-2-yl)butanoic acid;

Chemical Property of 2-(2-Methyl-1.3-dioxolan-2-yl)acetic acid

Chemical Property:

• PSA: 55.76000
• LogP: 0.22410

Purity/Quality:

99%, ^*data from raw suppliers

(2-methyl-[1,3]dioxolan-2-yl)-aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Methyl-1.3-dioxolan-2-yl)acetic acid

There total 7 articles about 2-(2-Methyl-1.3-dioxolan-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (2-methyl-1,3-dioxolan-2-yl)acetate (56446-60-7) → (2-methyl-[1,3]dioxolan-2-yl)-acetic acid (5735-97-7)

Guidance literature:

With potassium hydroxide; In water; Heating;

Reference yield: 93.0%

fructone (6413-10-1) → (2-methyl-[1,3]dioxolan-2-yl)-acetic acid (5735-97-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1002/ejoc.201600268

Reference yield: 91.0%

ethyl acetoacetate (141-97-9) + ethylene glycol (107-21-1) → (2-methyl-[1,3]dioxolan-2-yl)-acetic acid (5735-97-7) + fructone (6413-10-1)

Guidance literature:

β-1 zeolite; In toluene; at 145.85 ℃; for 1h; Further Variations:; Catalysts; Temperatures; Pressures; Product distribution;

DOI:10.1006/jcat.2000.3044

upstream raw materials:

fructone

methyl (2-methyl-1,3-dioxolan-2-yl)acetate

ethyl acetoacetate

ethylene glycol

Refernces

• 1、 Climent,Corma,Velty,Susarte. "Zeolites for the Production of Fine Chemicals: Synthesis of the Fructone Fragrancy". . p. 345 - 351. Retrieved 2000.
• 2、 -. "HPLC FREE PURIFICATION OF PEPTIDES BY THE USE OF NEW CAPPING AND CAPTURE REAGENTS". Page/Page column 16; 18. . Retrieved 2020/07/25.
• 3、 Liu, Qingyin,Mu, Yu,An, Qi,Xun, Jiali,Ma, Jian,Wu, Wenxi,Xu, Minjuan,Xu, Jun,Han, Li,Huang, Xueshi. "Total synthesis and anti-inflammatory evaluation of violacin A and its analogues". . . Retrieved 2019/11/26.