2-TERT-BUTYLPYRIDINE

Base Information

• Chemical Name: 2-TERT-BUTYLPYRIDINE
• CAS No.: 5944-41-2
• Molecular Formula: C9H13 N
• Molecular Weight: 135.209
• Hs Code.: 2933399090
• Mol file: 5944-41-2.mol

Synonyms:Pyridine,2-tert-butyl- (6CI,7CI,8CI); 2-tert-Butylpyridine

Chemical Property of 2-TERT-BUTYLPYRIDINE

Chemical Property:

• Vapor Pressure: 1.5mmHg at 25°C
• Melting Point: -33°C
• Refractive Index: 1.4891
• Boiling Point: 176.1°C at 760 mmHg
• PKA: pK1: 5.76(+1) (25°C)
• Flash Point: 35.9°C
• PSA: 12.89000
• Density: 0.905g/cm³
• LogP: 2.37910
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-tert-butylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-TERT-BUTYLPYRIDINE

There total 7 articles about 2-TERT-BUTYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

2-pyridyl tert-butyl sulfoxide (116249-84-4) → 2-Ethylpyridine (100-71-0) + 2-tert-butylpyridine (5944-41-2)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1080/10426509608037965

Reference yield: 24.0%

ethylmagnesium bromide (925-90-6) + 2-pyridyl tert-butyl sulfoxide (116249-84-4) → 2-Ethylpyridine (100-71-0) + 2-tert-butylpyridine (5944-41-2)

Guidance literature:

In tetrahydrofuran; for 0.25h; Ambient temperature;

DOI:10.1080/10426509608037965

Reference yield: 23.0%

tert-butylmercury chloride (38442-51-2) + 1-Methoxypyridinium iodide (22581-65-3) → 4-tert-butylpyridine (3978-81-2) + 2-tert-butylpyridine (5944-41-2) + 2,4-di-tert-butylpyridine (29939-31-9)

Guidance literature:

With potassium iodide; In dimethyl sulfoxide; at 35 - 40 ℃; for 0.5h; Irradiation;

DOI:10.1021/jo00122a013

upstream raw materials:

pyridine

tert-butylmercury chloride

tert-butylmercury iodide

ethylmagnesium bromide

Downstream raw materials:

2-isopropyl-6-t-butylpyridine

2,6-di-tert-butyl-pyridine

[(2-phenylindenyl)2Zr(2-t-butylpyridyl)][CH₃B(C₆F₅)3]

[(2-phenylindenyl)2Zr(2-tert-butylpyridyl)][tetrakis(pentafluorophenyl)borate]

Refernces

• 1、 Oae, Shigeru,Takeda, Takeshi,Uenishi, Junichi,Wakabayashi, Shoji. "Ligand coupling reactions of 2-pyridyl, 4-pyridyl and 2-pyrimidyl sulfoxides with grignard reagents". . p. 179 - 182. Retrieved 2007/10/03.
• 2、 Russell, Glen A.,Rajaratnam, Rajine,Wang, Lijuan,Shi, Bing Zhi,Kim, Byeong Hyu,Yao, Ching Fa. "tert-butylation of pyridines, quinolines, and isoquinolines by tert-butylmercury halides". . p. 10596 - 10604. Retrieved 2007/10/02.