ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE

Base Information

• Chemical Name: ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE
• CAS No.: 21190-16-9
• Molecular Formula: C6H9N3O2
• Molecular Weight: 155.156
• Hs Code.: 2933290090
• Mol file: 21190-16-9.mol

Synonyms:Ethyl 4-amino-5-imidazolecarboxylate;

Chemical Property of ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.5E-06mmHg at 25°C
• Melting Point: 180-181 °C
• Refractive Index: 1.584
• Boiling Point: 391.2 °C at 760 mmHg
• PKA: 11.66±0.10(Predicted)
• Flash Point: 190.4 °C
• PSA: 81.00000
• Density: 1.318 g/cm³
• LogP: 0.74980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-amino-1H-imidazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE

There total 13 articles about ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethanol (64-17-5) + 4-amino-5-imidazolecarboxamide (360-97-4,932-15-0) → ethyl 4-amino-5-imidazolecarboxylate (21190-16-9)

Guidance literature:

With methanesulfonic acid; at 20 - 120 ℃; for 10h; Sealed tube;

Reference yield: 54.0%

ethanol (64-17-5) + 5-Aminoimidazole-4-carboxamide (360-97-4) → 5-amino-1H-imidazole-4-carboxylic acid ethyl ester (21190-16-9)

Guidance literature:

With sulfuric acid; at 120 ℃; for 24h; Sealed tube;

Reference yield: 45.0%

5-Aminoimidazole-4-carboxamide (360-97-4) → 5-amino-1H-imidazole-4-carboxylic acid ethyl ester (21190-16-9)

Guidance literature:

5-Aminoimidazole-4-carboxamide; With methanesulfonic acid; In ethanol; for 288h; Heating / reflux;

With sodium hydroxide; water; In water; at 0 ℃; pH=6;

upstream raw materials:

5-nitro-1⁽³⁾H-imidazole-4-carboxylic acid ethyl ester

formamidine hydrochloride

ethyl-2-aminocyano acetate

formamidine acetic acid

Downstream raw materials:

ethyl 5-amino-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazole-4-carboxylate

ethyl 4-amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)imidazole-5-carboxylate

ethyl 4-amino-1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl)imidazole-5-carboxylate

ethyl 5-amino-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)imidazole-4-carboxylate

Refernces

• 1、 Sadchikova,Kureneva,Shtokareva,Selezneva. "Reactions of 5-diazoimidazoles with steroid hydrazones". . p. 1470 - 1476. Retrieved 2004.
• 2、 -. "SUBSTITUTED IMIDAZOLECARBOXYLATE DERIVATIVES AND THE USE THEREOF". Paragraph 1007-1009. . Retrieved 2020/12/08.
• 3、 -. "SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS". Paragraph 0547; 0548. . Retrieved 2017/04/04.