3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 2-chlorophenyl 2-cyanoethyl ester

Base Information

• Chemical Name: 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 2-chlorophenyl 2-cyanoethyl ester
• CAS No.: 80817-39-6
• Molecular Formula: C₂₃H₂₆ClN₆O₈P
• Molecular Weight: 580.922
• Mol file: 80817-39-6.mol

Synonyms:

Chemical Property of 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 2-chlorophenyl 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 2-chlorophenyl 2-cyanoethyl ester

There total 13 articles about 3-Guanylic acid, 2-deoxy-N-(2-methyl-1-oxopropyl)-, 2-chlorophenyl 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide) (72351-28-1) → ibGdΦ(CNEt) (80817-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane / 2 h / 20 °C

2: 1-methylimidazole / dioxane / 3 h / 20 °C

3: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → ibGdΦ(CNEt) (80817-39-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dioxane / 1 h / 20 °C

2: dioxane / 2 h / 20 °C

3: 1-methylimidazole / dioxane / 3 h / 20 °C

4: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With triethylamine; benzenesulfonic acid; 1-methyl-1H-imidazole; In 1,4-dioxane; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

N-2-isobutyryl-5'-O-(dimethoxytrityl)-2'-deoxyguanosine 3'-(o-chlorophenyl β-cyanoethyl phosphate) (80817-36-3) → ibGdΦ(CNEt) (80817-39-6)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform; at 0 ℃; for 0.25h; Yield given;

DOI:10.1002/hlca.19820650803

upstream raw materials:

N-2-isobutyryl-5'-O-(dimethoxytrityl)-2'-deoxyguanosine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

3-Hydroxypropionitrile

N-isobutyryl-2'-deoxyguanosine

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

Downstream raw materials:

C₆₃H₆₀Cl₂N₈O₁₇P₂

C₆₁H₆₂Cl₂N₁₀O₁₇P₂*C₆H₁₅N

C₅₇H₅₇Cl₂N₇O₁₇P₂*C₆H₁₅N

C₆₄H₆₅Cl₂N₁₁O₁₇P₂

Refernces

• 1、 Ohtsuka,Iwai,Tokunaga,Ikehara. "Deoxyribonucleic acids (DNA) and related compounds. XIII. Synthesis of DNA duplexes containing a ribosome binding site". . p. 3153 - 3159. Retrieved 2007/10/02.