1-(morpholin-4-yl)-2-phenylethanone

Base Information

• Chemical Name: 1-(morpholin-4-yl)-2-phenylethanone
• CAS No.: 17123-83-0
• Molecular Formula: C12H15 N O2
• Molecular Weight: 205.257
• Mol file: 17123-83-0.mol

Synonyms:Morpholine,4-(phenylacetyl)- (6CI,7CI,8CI,9CI); 1-(4-Morpholinyl)-2-phenylethanone;4-(2-Phenylacetyl)morpholine; 4-(Phenylacetyl)morpholine;N-(Phenylacetyl)morpholine; NSC 39224; Phenylacetic morpholide

Chemical Property of 1-(morpholin-4-yl)-2-phenylethanone

Chemical Property:

• Vapor Pressure: 4.56E-06mmHg at 25°C
• Boiling Point: 382.9°C at 760 mmHg
• Flash Point: 185.4°C
• Density: 1.137g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(morpholin-4-yl)-2-phenylethanone

There total 31 articles about 1-(morpholin-4-yl)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + phenylacetic acid (103-82-2) → N-(phenylacetyl)morpholine (17123-83-0)

Guidance literature:

With phenylsilane; In acetonitrile; at 20 ℃; for 0.5h; Solvent; Reagent/catalyst; Kinetics;

DOI:10.1002/ejoc.201901660

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + phenylacetylene (536-74-3) → N-(phenylacetyl)morpholine (17123-83-0)

Guidance literature:

With 4-methylpyridine-1-oxide; chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II); In 1,2-dichloro-ethane; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b01993

Reference yield: 98.0%

phenylacetic acid (103-82-2) + 3-methyl-1-(morpholin-4-ylcarbonyl)-1H-imidazol-3-ium iodide → N-(phenylacetyl)morpholine (17123-83-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2008.06.096

upstream raw materials:

morpholine

phenylacetyl chloride

phenylacetic acid

4-acetylmorpholine

Downstream raw materials:

4-(phenyl-pyridin-2-yl-acetyl)-morpholine

N-phenylacetyl-3-methoxymorpholine

(2R,3R)-1,5-Di-morpholin-4-yl-2,3-diphenyl-pentane-1,5-dione

(2R,3S)-1,5-Di-morpholin-4-yl-2,3-diphenyl-pentane-1,5-dione

Refernces

• 1、 D'Amaral, Melissa C.,Jamkhou, Nick,Adler, Marc J.. "Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines". supporting information. p. 288 - 295. Retrieved 2021/01/28.
• 2、 Barreteau, Fabien,Battilocchio, Claudio,Browne, Duncan L.,Godineau, Edouard,Leitch, Jamie A.,Nicholson, William I.,Payne, Riley,Priestley, Ian. "Direct Amidation of Esters by Ball Milling**". supporting information. p. 21868 - 21874. Retrieved 2021/09/02.