2-furyl phenyl ketone

Base Information

• Chemical Name: 2-furyl phenyl ketone
• CAS No.: 2689-59-0
• Molecular Formula: C11H8 O2
• Molecular Weight: 172.183
• Hs Code.: 2932190090
• Mol file: 2689-59-0.mol

Synonyms:Ketone,2-furyl phenyl (6CI,7CI,8CI); (2-Furanyl)phenyl methanone; 2-Benzoylfuran;2-Furyl phenyl ketone; NSC 21618; Phenyl 2-furyl ketone

Chemical Property of 2-furyl phenyl ketone

Chemical Property:

• Vapor Pressure: 0.00276mmHg at 25°C
• Refractive Index: 1.6055 (estimate)
• Boiling Point: 285.7°Cat760mmHg
• Flash Point: 129°C
• PSA: 30.21000
• Density: 1.145g/cm³
• LogP: 2.51060

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-furyl phenyl ketone

There total 94 articles about 2-furyl phenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-furancarbonyl chloride (527-69-5) + phenylboronic acid (98-80-6) → (furan-2-yl)(phenyl)methanone (2689-59-0)

Guidance literature:

With PEG₂₀₀; sodium carbonate; palladium diacetate; at 60 ℃; for 1h;

DOI:10.1021/jo060749d

Reference yield: 98.0%

furan (110-00-9) + benzoic acid (65-85-0,8013-63-6) → (furan-2-yl)(phenyl)methanone (2689-59-0)

Guidance literature:

With aluminium dodecatungsten phosphate; trifluoroacetic anhydride; at 0 ℃; for 2.5h;

DOI:10.1016/S0040-4039(03)01199-7

Reference yield: 96.0%

tert-butyl (furan-2-carbonyl)(phenyl)carbamate + phenylboronic acid (98-80-6) → (furan-2-yl)(phenyl)methanone (2689-59-0)

Guidance literature:

With [Pd(1,3-bis(2,6-bis(-diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; water; potassium carbonate; In tetrahydrofuran; at 23 ℃; for 18h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/cctc.201800511

upstream raw materials:

furan

benzoyl fluoride

benzoyl chloride

benzoic acid anhydride

Downstream raw materials:

[2]Furyl-phenyl-[2]pyridyl-methanol

(5-(tert-butyl)furan-2-yl)(phenyl)methanone

(R)-2-furylphenylmethanol

(S)-2-furyl(phenyl)methanol

Refernces

• 1、 Zheng, Ye,Martinez-Acosta, Jaime A.,Khimji, Mohammed,Barbosa, Luiz C. A.,Clarkson, Guy J.,Wills, Martin. "Asymmetric Transfer Hydrogenation of Aryl Heteroaryl Ketones using Noyori-Ikariya Catalysts". . p. 4384 - 4391. Retrieved 2021/08/23.
• 2、 Chen, Zi-Yan,Deng, Xue-Zu,Song, Yang,Xue, Fei,Yamane, Motoki,Yue, Yan-Ni. "Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes". . p. 12693 - 12704. Retrieved 2021/09/28.