2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde
• CAS No.: 30384-93-1
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.1726
• Hs Code.: 2933990090
• European Community (EC) Number: 640-949-3
• DSSTox Substance ID: DTXSID90374949
• Nikkaji Number: J3.384.831E
• Wikidata: Q82163512
• Mol file: 30384-93-1.mol

Synonyms:2-methylimidazo[1,2-a]pyridine-3-carbaldehyde;30384-93-1;2-Methyl-imidazo[1,2-a]pyridine-3-carbaldehyde;2-methylimidazo[1,2-a]pyridine-3-carboxaldehyde;MFCD02251327;SCHEMBL858446;MCSIFRRJDAQKML-UHFFFAOYSA-;DTXSID90374949;MCSIFRRJDAQKML-UHFFFAOYSA-N;IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE, 2-METHYL-;AKOS000121641;AB11614;PS-5809;AM803662;BP-10987;BB 0258401;CS-0038253;FT-0677879;EN300-00962;2-methyl-h-imidazo[1,2-a]pyridine-3-carbaldehyde;A820349;J-510055;Z56792097;F2124-0673;2-Methyl-imidazo[1,2-a]pyridine-3-carbaldehyde, AldrichCPR;InChI=1/C9H8N2O/c1-7-8(6-12)11-5-3-2-4-9(11)10-7/h2-6H,1H3

Chemical Property of 2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

Chemical Property:

• Melting Point: 117-118 °C
• Refractive Index: 1.622
• PKA: 5.24±0.10(Predicted)
• PSA: 34.37000
• Density: 1.21 g/cm³
• LogP: 1.45520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 183

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N2C=CC=CC2=N1)C=O

Technology Process of 2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

There total 12 articles about 2-Methylimidazo[1,2-a]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2-methylimidazo[1,2-a]pyridine (934-37-2) + N-methyl-N-phenylformamide (93-61-8) → 2-metilimidazo<1,2-a>piridin-3-carbossaldeide (30384-93-1)

Guidance literature:

With tert.-butylhydroperoxide; cyclopentadienyltricarbonyliron; [copper(II)(trifluoroacetylacetonate)₂]; N-butylpyridine p-toluenesulfonate; In toluene; at 70 ℃; for 12h; Reagent/catalyst;

Reference yield: 95.0%

pyridin-3-yl-)methyl>phosphonsaeure-diisopropylester (89021-03-4) → 2-metilimidazo<1,2-a>piridin-3-carbossaldeide (30384-93-1)

Guidance literature:

With sodium hydroxide; water; for 5h;

DOI:10.1016/S0040-4039(00)94151-0

Reference yield: 80.0%

2-methylimidazo[1,2-a]pyridine (934-37-2) + dimethyl sulfoxide (67-68-5,8070-53-9) → 2-metilimidazo<1,2-a>piridin-3-carbossaldeide (30384-93-1)

Guidance literature:

With iron(III) chloride; oxygen; acetic acid; at 100 ℃; for 12h; under 760.051 Torr; chemoselective reaction;

DOI:10.1016/j.tetlet.2016.07.057

upstream raw materials:

2-methylimidazo[1,2-a]pyridine

N,N-dimethyl-formamide

pyridin-3-yl-)methyl>phosphonsaeure-diisopropylester

2-Methyl-3-(2,2,2-trichloro-1-hydroxyethyl)imidazo<1,2-a>pyridine

Downstream raw materials:

2-methyl-3-(4-phenylpiperazinylmethyl)imidazo[1,2-a]-pyridine

2-methyl-3-[4-(4-chlorophenyl) piperazinylmethyl]imidazo-[1,2-a]-pyridine

1-(2-methylimidazo[1,2-a]pyridin-3-yl)ethanone

C₁₉H₂₀N₄O₃

Refernces

• 1、 García-Carrillo, Mario Alfredo,Guzmán, ángel,Díaz, Eduardo. "Metal free coupling of heteroaryl N-tosylhydrazones and thiols: Efficient synthesis of sulfides". supporting information. p. 1952 - 1956. Retrieved 2017/04/27.
• 2、 -. "A formyl Heteraromatic hydrocarbons the synthetic method of the compound of pharmaceutical intermediates". Paragraph 0031-0035. . Retrieved 2017/05/04.