3-(Trimethylsilyl)-1-propanol

Base Information

• Chemical Name: 3-(Trimethylsilyl)-1-propanol
• CAS No.: 2917-47-7
• Molecular Formula: C6H16OSi
• Molecular Weight: 132.278
• Hs Code.: 29310099
• European Community (EC) Number: 627-628-3
• NSC Number: 96794
• UNII: 6X3S2Y526B
• DSSTox Substance ID: DTXSID5062710
• Nikkaji Number: J364.741B
• Wikidata: Q81990208
• Mol file: 2917-47-7.mol

Synonyms:3-(Trimethylsilyl)-1-propanol;2917-47-7;3-(trimethylsilyl)propan-1-ol;1-Propanol, 3-(trimethylsilyl)-;3-trimethylsilylpropan-1-ol;3-trimethylsilylpropanol;3-(Trimethylsilyl)propanol;3-trimethylsilyl-1-propanol;6X3S2Y526B;NSC 96794;NSC-96794;NSC96794;3-hydroxytrimethylsilane;4,4-dimethyl-4-silapentanol;SCHEMBL402873;UNII-6X3S2Y526B;Trimethyl-3-hydroxypropylsilane;DTXSID5062710;MFCD00009712;AKOS015916454;3-(Trimethylsilyl)-1-propanol, 97%;SB84202;s20075;3-(TRIMETHYLSILYL)-1-PROPANOL?;AS-80812;FT-0730459;F87269;A852346;J-017419

Chemical Property of 3-(Trimethylsilyl)-1-propanol

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 2.45mmHg at 25°C
• Melting Point: < 0 °C
• Refractive Index: n20/D 1.428(lit.)
• Boiling Point: 141 °C at 760 mmHg
• Flash Point: 52.8 °C
• PSA: 20.23000
• Density: 0.822 g/cm³
• LogP: 1.70700
• Storage Temp.: Flammables area
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 132.097041664
• Heavy Atom Count: 8
• Complexity: 56

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Trimethylsilyl-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[Si](C)(C)CCCO
• Uses: 3-(Trimethylsilyl)-1-propanol has been used in:the synthesis of telechelic oligomers via atom transfer radical polymerization (ATRP) of styrenethe preparation of the β-seleno-γ-silyl alcohols

Technology Process of 3-(Trimethylsilyl)-1-propanol

There total 15 articles about 3-(Trimethylsilyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

chloro-trimethyl-silane (75-77-4) + 3-chloromagnesiumpropan-1-olate magnesium chloride (68236-10-2) → 3-trimethylsilyl-1-propanol (2917-47-7)

Guidance literature:

DOI:10.1016/S0040-4039(00)96045-3

Reference yield: 71.0%

oxirane (75-21-8,99932-75-9) + (trimethylsilyl)methylmagnesium chloride (13170-43-9) → 3-trimethylsilyl-1-propanol (2917-47-7)

Guidance literature:

With HCl; In not given; (CH3)3SiCH2MgCl and ethylene oxide; hydrolysis with HCl;;

DOI:10.1021/ja01177a033 DOI:10.1021/ja01124a039

Reference yield: 52.0%

(3-chloropropoxy)trimethylsilane (18171-15-8) → 3-trimethylsilyl-1-propanol (2917-47-7)

Guidance literature:

With lithium; In pentane; for 4h; Heating;

DOI:10.1016/S0022-328X(00)89867-8

upstream raw materials:

oxirane

(trimethylsilyl)methylmagnesium chloride

(3-chloropropoxy)trimethylsilane

chloro-trimethyl-silane

Downstream raw materials:

[3-(2-chloro-5-methyl-4-nitrophenoxy)propyl]trimethylsilane

[3-(2,5-dichloro-4-nitrophenoxy)propyl]trimethylsilane

3-(trimethylsilyl)propyl bromide

2-(pentafluorophenyl)-3,4-bis(3-trimethylsilylpropoxy)-5-trimethylsilylthiophene

Refernces

• 1、 Cytarska,Kaczanowska,Zaidlewicz. "Synthesis of silylated alkylboronic acids and esters via hydroboration of allylic and vinylic trimethylsilanes". . p. 1587 - 1594. Retrieved 2008/09/18.
• 2、 Sarkar, Tarun K.,Ghosh, Sunil K.. "SILICON-CONTROLLED REARRANGEMENT VERSUS KRIEF-REICH REACTION IN β-SELENO-γ-SILYL ALCOHOLS : A NEW STEREOSELECTIVE SYNTHESIS OF TERMINALLY-SUBSTITUTED ALLYLSILANES". . p. 2061 - 2064. Retrieved 2007/10/02.