N-CBZ-L-GLUTAMIC ACID ALPHA-METHYL ESTER DICYCLOHEXYL AMMONIUM SALT

Base Information

• Chemical Name: N-CBZ-L-GLUTAMIC ACID ALPHA-METHYL ESTER DICYCLOHEXYL AMMONIUM SALT
• CAS No.: 5672-82-2
• Molecular Formula: C26H40N2O6
• Molecular Weight: 0
• Mol file: 5672-82-2.mol

Synonyms:5-Benzyl N-Cbz-L-glutamate;N-Cbz-L-Glutamic Acid alpha-Methyl Ester Dicyclohexyl Ammonium Salt;N-benzyloxycarbonyl-L-glutamic acid-5-benzyl ester;N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid;N-Z-L-Glu-OMe-4g-Dcha salt;

Chemical Property of N-CBZ-L-GLUTAMIC ACID ALPHA-METHYL ESTER DICYCLOHEXYL AMMONIUM SALT

Chemical Property:

• Vapor Pressure: 2.96E-18mmHg at 25°C
• Boiling Point: 510.6°Cat760mmHg
• Flash Point: 262.6°C
• PSA: 113.96000
• Density: g/cm³
• LogP: 5.34240

Purity/Quality:

90%,98% ^*data from raw suppliers

N-Cbz-L-GlutamicAcidα-MethylEsterDicyclohexylAmmoniumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CBZ-L-GLUTAMIC ACID ALPHA-METHYL ESTER DICYCLOHEXYL AMMONIUM SALT

There total 2 articles about N-CBZ-L-GLUTAMIC ACID ALPHA-METHYL ESTER DICYCLOHEXYL AMMONIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + N-benzyloxycarbonyl-L-glutamic acid (1155-62-0) + N-cyclohexyl-cyclohexanamine (101-83-7) → N-Z-L-Glu-OMe-4g-Dcha salt (5672-82-2,26566-10-9)

Guidance literature:

N-benzyloxycarbonyl-L-glutamic acid; With acetic anhydride; at 45 ℃;

methanol; Heating;

N-cyclohexyl-cyclohexanamine; Further stages.;

Reference yield:

methanol (67-56-1) + N-cyclohexyl-cyclohexanamine (101-83-7) + N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → N-Z-L-Glu-OMe-4g-Dcha salt (5672-82-2,26566-10-9)

Guidance literature:

Reference yield: 81.2%

N-Z-L-Glu-OMe-4g-Dcha salt (5672-82-2,26566-10-9) + (S)-methyl 2-amino-3-(methylthio)propanoate hydrochloride (95244-77-2) → C19H26N2O7S

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1080/09168451.2018.1436433

upstream raw materials:

methanol

N-cyclohexyl-cyclohexanamine

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

N-benzyloxycarbonyl-L-glutamic acid

Downstream raw materials:

N-(N-benzyloxycarbonyl-O-methyl-L-γ-glutamyl)-glycine ethyl ester

Z-L-GluOMe

methyl (S)-2-benzyloxycarbonylamino-6-diazo-5-oxohexanoate

Refernces