2,3-Dimethoxybenzamide

Base Information

• Chemical Name: 2,3-Dimethoxybenzamide
• CAS No.: 1521-39-7
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• Hs Code.: 29420000
• European Community (EC) Number: 668-204-8
• NSC Number: 40843,2353
• DSSTox Substance ID: DTXSID60277438
• Nikkaji Number: J534.074H
• Wikidata: Q82008597
• ChEMBL ID: CHEMBL458644
• Mol file: 1521-39-7.mol

Synonyms:2,3-Dimethoxybenzamide;1521-39-7;o-Veratramide;dimethoxybenzamide;NSC2353;SCHEMBL261504;CHEMBL458644;SDYIZAANGZBOSO-UHFFFAOYSA-;DTXSID60277438;NSC 2353;NSC-2353;NSC40843;MFCD00017571;NSC 40843;NSC-40843;AKOS005151365;FS-3962;CS-0186489;D2283;FT-0633632;C13919;A809264;J-008893;Z33546668

Chemical Property of 2,3-Dimethoxybenzamide

Chemical Property:

• Melting Point: 94 °C
• Boiling Point: 273.2 °C at 760 mmHg
• PKA: 15.40±0.50(Predicted)
• Flash Point: 121.3 °C
• PSA: 61.55000
• Density: 1.16 g/cm³
• LogP: 1.50300
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dimethoxybenzamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)C(=O)N

Technology Process of 2,3-Dimethoxybenzamide

There total 6 articles about 2,3-Dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dimethoxybenzonitrile (5653-62-3) → 2,3-dimethoxybenzamide (1521-39-7)

Guidance literature:

With polystyrene-triethylenetetramine anchored ruthenium(II) complex; air; In water; at 90 ℃; for 7h; Green chemistry;

DOI:10.1002/aoc.3233

Reference yield: 80.0%

2,3-dimethoxybenzyl alcohol (5653-67-8) → 2,3-dimethoxybenzamide (1521-39-7)

Guidance literature:

With ammonium hydroxide; In water; at 120 ℃; for 24h; under 7500.75 Torr; Sealed tube; Autoclave;

DOI:10.1016/j.chempr.2021.12.001

Reference yield: 44.0%

2,3-dimethoxybenzoyl chloride (7169-06-4) → 2,3-dimethoxybenzamide (1521-39-7)

Guidance literature:

With ammonium hydroxide;

DOI:10.1016/0040-4020(80)80221-3

upstream raw materials:

2,3-dimethoxybenzoyl chloride

2,3-dimethoxybenzoic acid

2,3-dimethyoxybenzaldehyde

2,3-dimethoxybenzonitrile

Downstream raw materials:

2',6-dimethoxy-(1,1'-biphenyl)-2-carboxaldehyde

(4S,5S)-4-Methoxymethyl-2-(6-methoxy-2'-methyl-biphenyl-2-yl)-5-phenyl-4,5-dihydro-oxazole

(4S,5S)-2-(6,2'-Dimethoxy-biphenyl-2-yl)-4-methoxymethyl-5-phenyl-4,5-dihydro-oxazole

(1S,2S)-3-Methoxy-2-[(6-methoxy-2'-methyl-biphenyl-2-ylmethyl)-amino]-1-phenyl-propan-1-ol

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF 2,3-DIHYDROXY BENZONITRILE". Paragraph 0069. . Retrieved 2015/07/02.
• 2、 Islam, Sk Manirul,Ghosh, Kajari,Roy, Anupam Singha,Molla, Rostam Ali. "Polymer-anchored Ru(II) complex as an efficient catalyst for the synthesis of primary amides from nitriles and of secondary amides from alcohols and amines". . p. 900 - 907. Retrieved 2015/02/19.