2,3-Dimethoxybenzyl alcohol

Base Information

• Chemical Name: 2,3-Dimethoxybenzyl alcohol
• CAS No.: 5653-67-8
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Hs Code.: 29094980
• European Community (EC) Number: 227-099-5
• NSC Number: 403220,87568
• UNII: 67HS6Y2X2R
• DSSTox Substance ID: DTXSID20205090
• Nikkaji Number: J149.880K
• Wikidata: Q72467708
• Mol file: 5653-67-8.mol

Synonyms:2,3-Dimethoxybenzyl alcohol;5653-67-8;(2,3-Dimethoxyphenyl)methanol;o-Veratryl alcohol;Benzenemethanol, 2,3-dimethoxy-;2,3-Dimethoxybenzylalcohol;2,3-Dimethoxybenzylic Alcohol;EINECS 227-099-5;NSC-87568;NSC-403220;AI3-20629;2,3-Dimethoxybenzenemethanol;2,3-Dimethoxybenzylic alcohol;NSC 403220;NSC 87568;O(C)c1c(CO)cccc1OC;SCHEMBL95873;67HS6Y2X2R;DTXSID20205090;(2,3-Dimethoxyphenyl)methanol #;CS-Z0027;NSC87568;2,3-Dimethoxybenzyl alcohol, 99%;BBL027468;MFCD00004612;NSC403220;STL354191;AKOS000120834;AS-40108;D1764;FT-0609680;EN300-20826;AP-065/41950909

Chemical Property of 2,3-Dimethoxybenzyl alcohol

Chemical Property:

• Appearance/Colour: Off-white powder.
• Vapor Pressure: 0.00743mmHg at 25°C
• Melting Point: 48-51 °C
• Refractive Index: 1.521
• Boiling Point: 257.5 °C at 760 mmHg
• PKA: 14.16±0.10(Predicted)
• Flash Point: 113.6 °C
• PSA: 38.69000
• Density: 1.111 g/cm³
• LogP: 1.19610
• Storage Temp.: Refrigerator
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

2,3-DimethoxybenzylicAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36/37-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)CO
• Uses: 2,3-Dimethoxybenzylic Alcohol, is a substituted benzaldehyde, which has been shown to have Antimicrobial activity. 2,3-Dimethoxybenzyl alcohol has been used to study the solvent isotope effect (D2O versus H2O) on photomethanolysis efficiency and on fluorescence intensity.

Technology Process of 2,3-Dimethoxybenzyl alcohol

There total 13 articles about 2,3-Dimethoxybenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dimethyoxybenzaldehyde (86-51-1) → 2,3-dimethoxybenzyl alcohol (5653-67-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

Reference yield: 99.0%

2-(2,3-dimethoxy-benzyloxy)-tetrahydro-pyran → 2,3-dimethoxybenzyl alcohol (5653-67-8)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; In methanol; for 0.0333333h; Heating;

DOI:10.1081/SCC-120004252

Reference yield: 93.0%

C22H24O3Si → 2,3-dimethoxybenzyl alcohol (5653-67-8)

Guidance literature:

With 18-crown-6 ether; In ethanol; water; at 45 ℃; for 2.5h; Reagent/catalyst; Solvent; Temperature; Green chemistry;

DOI:10.1002/cctc.201901232

upstream raw materials:

2,3-dimethyoxybenzaldehyde

2,3-dimethoxybenzoic acid

ethanol

2,3-dimethoxybenzamide

Downstream raw materials:

(5-bromo-2,3-dimethoxyphenyl)methanol

2,3-dimethoxy-5-nitro-benzyl alcohol

2,3-dimethoxybenzyl chloride

2,3-dimethoxybenzyl bromide

Refernces

• 1、 Vilches-Herrera, Marcelo,Gallardo-Fuentes, Sebastián,Aravena-Opitz, Mauricio,Yá?ez-Sánchez, Mauricio,Jiao, Haijun,Holz, Jens,B?rner, Armin,Lühr, Susan. "Reduction over Condensation of Carbonyl Compounds through a Transient Hemiaminal Intermediate Using Hydrazine". . p. 9213 - 9218. Retrieved 2020/08/14.
• 2、 Akporji, Nnamdi,Lieberman, Josh,Maser, Michael,Yoshimura, Masahiko,Boskovic, Zarko,Lipshutz, Bruce H.. "Selective Deprotection of the Diphenylmethylsilyl (DPMS) Hydroxyl Protecting Group under Environmentally Responsible, Aqueous Conditions". . p. 5743 - 5747. Retrieved 2019/11/11.