Technology Process of delta(1)-thienamycin
There total 5 articles about delta(1)-thienamycin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
for 0.5h;
Ambient temperature;
phosphate buffer pH 7;
DOI:10.1021/jm00137a032
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 24 percent / 1,5-diazabicyclo<5.4.0>ondec-5-ene / dimethylsulfoxide / 0.17 h / Ambient temperature
2: 63 percent / H2 / 10percent Pd/c / tetrahydrofuran; ethanol / 0.5 h / Ambient temperature; phosphate buffer pH 7
With
hydrogen; 1,5-Diazabicyclo[5.4.0]undec-5-ene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00137a032
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaHCO3, 2.) LiOH / 1.) H2O, dioxane, 10 min, 2.) EtOAc
2: HMPA / 2.5 h / Ambient temperature
3: 24 percent / 1,5-diazabicyclo<5.4.0>ondec-5-ene / dimethylsulfoxide / 0.17 h / Ambient temperature
4: 63 percent / H2 / 10percent Pd/c / tetrahydrofuran; ethanol / 0.5 h / Ambient temperature; phosphate buffer pH 7
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; hydrogen; sodium hydrogencarbonate; 1,5-Diazabicyclo[5.4.0]undec-5-ene;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00137a032
