hematinic acid

Base Information

• Chemical Name: hematinic acid
• CAS No.: 487-65-0
• Molecular Formula: C8H9 N O4
• Molecular Weight: 183.164
• Mol file: 487-65-0.mol

Synonyms:3-Pyrroline-3-propionicacid, 4-methyl-2,5-dioxo- (6CI,7CI,8CI); Biliverdic acid; Hematinic acid

Chemical Property of hematinic acid

Chemical Property:

• Vapor Pressure: 6.32E-08mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Boiling Point: 411.5°Cat760mmHg
• Flash Point: 202.7°C
• PSA: 86.96000
• Density: 1.349g/cm³
• LogP: 0.10000
• Water Solubility.: 39g/L(20 oC)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hematinic acid

There total 30 articles about hematinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-(4-Methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-ylmethyl)-malonic acid diethyl ester (208333-71-5) → 3-(4-methyl-2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-propionic acid (487-65-0)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1080/00397919808007020

Reference yield:

sulfuric acid (7664-93-9) + 3,3'-((4S,16S)-2t,17c'-diethyl-3c,7,13,18t'-tetramethyl-1,19-dioxo(4rH,16r'H)-2,3,4,5,15,16,17,18,19,21,22,24-dodecahydro-1H-bilin-8,12-diyl)-di-propionic acid ; hydrochloride → 3-(4-methyl-2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-propionic acid (487-65-0) + succinic acid (110-15-6) + acetic acid (64-19-7,77671-22-8)

Guidance literature:

Produkt 5: CO₂;

DOI:10.1039/jr9580003085 DOI:10.1073/pnas.68.9.2141

Reference yield:

2-Methyl-3-vinylmaleimide (21494-57-5) → 3-(4-methyl-2,5-dioxo-2,5-dihydro-pyrrol-3-yl)-propionic acid (487-65-0)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; at 90 ℃;

DOI:10.1021/ja00216a070

upstream raw materials:

2-propionic-3-methylmaleic anhydride

urea

Hematinic acid methyl ester

mesoporphyrin IX

Downstream raw materials:

3-ethyl-4-methyl-pyrrole-2,5-dione

Refernces

• 1、 Brynjelsen, Sean E.,Doty, Mark,Poss, Mitchell J.. "Facile synthesis of hematinic acid". . p. 1885 - 1889. Retrieved 1998.