L-Methionylglycine

Base Information

• Chemical Name: L-Methionylglycine
• CAS No.: 14486-03-4
• Deprecated CAS: 13111-10-9
• Molecular Formula: C7H14N2O3S
• Molecular Weight: 206.266
• Hs Code.: 2930909090
• European Community (EC) Number: 238-487-9
• UNII: T872MM2E20
• DSSTox Substance ID: DTXSID401020087
• Nikkaji Number: J81.776G
• Wikidata: Q27141928
• Metabolomics Workbench ID: 78903
• ChEMBL ID: CHEMBL90972
• Mol file: 14486-03-4.mol

Synonyms:L-methionylglycine;Met-Gly;methionylglycine

Chemical Property of L-Methionylglycine

Chemical Property:

• Appearance/Colour: White to off white powder
• Vapor Pressure: 7.78E-11mmHg at 25°C
• Melting Point: 212 ºC
• Refractive Index: 1.541
• Boiling Point: 487.4 ºC at 760 mmHg
• PKA: 3.09±0.10(Predicted)
• Flash Point: 248.6 ºC
• PSA: 117.72000
• Density: 1.267 g/cm³
• LogP: 0.35880
• Storage Temp.: −20°C
• Water Solubility.: almost transparency
• XLogP3: -3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 206.07251349
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

98% ^*data from raw suppliers

(S)-2-(2-Amino-4-(methylthio)butanamido)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CSCCC(C(=O)NCC(=O)O)N
• Isomeric SMILES: CSCC[C@@H](C(=O)NCC(=O)O)N

Technology Process of L-Methionylglycine

There total 10 articles about L-Methionylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Met-Gly-OH (13139-55-4) → N-L-methionyl-glycine (14486-03-4)

Guidance literature:

With methanol; palladium; durch Hydrogenolyse;

Reference yield:

5,5-Dimethyl-1-pyrroline N-oxide (3317-61-1) + H-Met-Gly-NHNHPh*TFA → (2,2-dimethyl-5-phenyl-1-pyrrolidinyl)oxy radical (40936-12-7) + N-L-methionyl-glycine (14486-03-4)

Guidance literature:

With phosphate buffer; oxygen; tyrosinase; at 20 ℃; for 0.116667h; pH=7.0;

DOI:10.1021/jo0259966

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) → N-L-methionyl-glycine (14486-03-4)

Guidance literature:

Multi-step reaction with 4 steps

2: dicyclohexylcarbodiimide

3: aqueous NaHCO₃ / tetrahydrofuran; H₂O

4: 1.) trifluoroacetic acid, 2.) aqueous ammonia

With ammonium hydroxide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1039/DT9840002305

upstream raw materials:

Z-Met-Gly-OH

2-((2S)-2-((tert-butoxycarbonyl)amino)-4-(methylthio)butanamido)acetic acid

5,5-Dimethyl-1-pyrroline N-oxide

L-methionine

Downstream raw materials:

methionine S-oxide

carbon dioxide

4-carboxybenzophenone radical

benzophenone-4-carboxylic acid radical anion

Refernces

• 1、 Hug, Gordon L.,Bobrowski, Krzysztof,Kozubek, Halina,Marciniak, Bronislaw. "Photooxidation of Methionine Derivatives by the 4-Carboxybenzophenone Triplet State in Aqueous Solution. Intracomplex Proton Transfer Involving the Amino Group". . p. 785 - 796. Retrieved 2007/10/03.