4-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE

Base Information

• Chemical Name: 4-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE
• CAS No.: 19837-74-2
• Molecular Formula: C13H14N2O3S
• Molecular Weight: 278.332
• Hs Code.: 2935009090
• Mol file: 19837-74-2.mol

Synonyms:p-Sulfanilanisidide (7CI,8CI);4-Amino-N-(4-methoxyphenyl)benzenesulfonamide;N-(4-Methoxyphenyl) 4-aminobenzenesulfonamide;N1-p-Methoxyphenylsulanilamide;

Chemical Property of 4-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 2.8E-09mmHg at 25°C
• Refractive Index: 1.641
• Boiling Point: 477.4 °C at 760 mmHg
• Flash Point: 242.5 °C
• PSA: 89.80000
• Density: 1.358 g/cm³
• LogP: 3.81320

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-(4-methoxy-phenyl)-benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE

There total 8 articles about 4-AMINO-N-(4-METHOXY-PHENYL)-BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-(4-methoxyphenyl)-4-nitrobenzene sulphonamide (10553-17-0) → N-(4-methoxyphenyl)-4-aminobenzenesulfonamide (19837-74-2)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In methanol; at 20 ℃;

DOI:10.1002/cplu.202000326

Reference yield: 92.0%

N-(4-(N-(4-methoxyphenyl)sulfamoyl)phenyl)acetamide (19837-89-9) → N-(4-methoxyphenyl)-4-aminobenzenesulfonamide (19837-74-2)

Guidance literature:

With sulfuric acid; water; for 0.3h; Reflux;

DOI:10.1007/s13738-021-02344-3

Reference yield: 89.0%

→ N-(4-methoxyphenyl)-4-aminobenzenesulfonamide (19837-74-2)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 70 ℃; for 12h;

upstream raw materials:

N-(4-(N-(4-methoxyphenyl)sulfamoyl)phenyl)acetamide

4-methoxy-aniline

p-acetylaminobenzenesulfonyl chloride

N-(4-methoxyphenyl)-4-nitrobenzene sulphonamide

Downstream raw materials:

C₃₀H₂₃N₅O₃S

N-(4-methoxyphenyl)-4-[(3,4-diphenylpyrimido[4',5':4,5]thieno[2,3-c]pyridazin-8-yl)amino]benzenesulfonamide

6-chloro-1-(2-hydroxyethyl)-4-oxo-1,4-dihydro[1,7]phenanthroline-3-carboxylic acid [4-(4-methoxyphenylsulfamoyl)phenyl]amide

6-hydroxy-1-(2-hydroxyethyl)-4-oxo-1,4-dihydro[1,7]phenanthroline-3-carboxylic acid [4-(4-methoxyphenylsulfamoyl)phenyl]amide

Refernces

• 1、 Silveira, Flávia F.,de Souza, Juliana O.,Hoelz, Lucas V.B.,Campos, Vinícius R.,Jabor, Valquíria A.P.,Aguiar, Anna C.C.,Nonato, M. Cristina,Albuquerque, Magaly G.,Guido, Rafael V.C.,Boechat, Nubia,Pinheiro, Luiz C.S.. "Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors". . . Retrieved 2020/11/10.
• 2、 ?imková, Ludmila,Císa?ová, Ivana,Cu?ínová, Petra,Ludvík, Ji?í,Sykora, Jan,Salvadori, Karolína. "Sulphonamidic Groups as Electron-Withdrawing Units in Ureido-Based Anion Receptors: Enhanced Anion Complexation versus Deprotonation". . p. 1401 - 1411. Retrieved 2020/08/05.