N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE

Base Information

• Chemical Name: N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE
• CAS No.: 19837-89-9
• Molecular Formula: C15H16N2O4S
• Molecular Weight: 320.369
• Hs Code.: 2935009090
• Mol file: 19837-89-9.mol

Synonyms:F0808-1284;4-Acetylamino-benzolsulfonsaeure-p-anisidid;Essigsaeure-[4-(4-methoxy-phenylsulfamoyl)-anilid];N4-Acetyl-N1-(p-methoxy-phenyl)-sulfanilamid;N-acetyl-sulfanilic acid p-anisidide;n-{4-[(4-methoxyphenyl)sulfamoyl]phenyl}acetamide;N-(4-methoxyphenyl)-4-(acetylamino)benzenesulfonamide;N-Acetyl-sulfanilsaeure-p-anisidid;

Chemical Property of N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 92.88000
• Density: 1.359g/cm³
• LogP: 3.68120

Purity/Quality:

99%min ^*data from raw suppliers

N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE

There total 4 articles about N4-ACETYL-N1-(4-METHOXYPHENYL)SULFANILAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxy-aniline (104-94-9) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-(4-(N-(4-methoxyphenyl)sulfamoyl)phenyl)acetamide (19837-89-9)

Guidance literature:

With sodium hydrogencarbonate; In neat (no solvent); at 20 ℃; for 0.25h;

DOI:10.1007/s13738-021-02344-3

Reference yield: 88.0%

→ N-(4-(N-(4-methoxyphenyl)sulfamoyl)phenyl)acetamide (19837-89-9)

Guidance literature:

With triethylamine; In dichloromethane; for 0.333333h;

In dichloromethane; at 20 ℃; for 4.5h; Cooling with ice;

Reference yield:

Acetanilid (103-84-4) → N-(4-(N-(4-methoxyphenyl)sulfamoyl)phenyl)acetamide (19837-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0 - 60 °C

2: triethylamine / chloroform / 5 h / 61 °C

With chlorosulfonic acid; triethylamine; In chloroform;

DOI:10.1016/j.ejmech.2020.112941

upstream raw materials:

4-methoxy-aniline

p-acetylaminobenzenesulfonyl chloride

Acetanilid

aniline

Downstream raw materials:

N-(4-methoxyphenyl)-4-aminobenzenesulfonamide

Refernces

• 1、 Silveira, Flávia F.,de Souza, Juliana O.,Hoelz, Lucas V.B.,Campos, Vinícius R.,Jabor, Valquíria A.P.,Aguiar, Anna C.C.,Nonato, M. Cristina,Albuquerque, Magaly G.,Guido, Rafael V.C.,Boechat, Nubia,Pinheiro, Luiz C.S.. "Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors". . . Retrieved 2020/11/10.
• 2、 Wang, Xu,Ahn, Yong-Mo,Lentscher, Adam G.,Lister, Julia S.,Brothers, Robert C.,Kneen, Malea M.,Gerratana, Barbara,Boshoff, Helena I.,Dowd, Cynthia S.. "Design, synthesis, and evaluation of substituted nicotinamide adenine dinucleotide (NAD+) synthetase inhibitors as potential antitubercular agents". supporting information. p. 4426 - 4430. Retrieved 2017/09/12.