2-Aminotetradecanoic acid

Base Information

• Chemical Name: 2-Aminotetradecanoic acid
• CAS No.: 7145-63-3
• Molecular Formula: C14H29 N O2
• Molecular Weight: 243.3856
• NSC Number: 74445
• Nikkaji Number: J1.213.377D
• Metabolomics Workbench ID: 1840
• Mol file: 7145-63-3.mol

Synonyms:2-aminotetradecanoic acid;7145-63-3;2-amino-tetradecanoic acid;Tetradecanoic acid,2-amino-;NSC74445;2-aminotetradecanoicacid;alpha-aminotetradecanoic acid;SCHEMBL660684;CHEBI:165350;LMFA01100007;NSC-74445;AKOS011344896;AB88437;AB89099

Chemical Property of 2-Aminotetradecanoic acid

Chemical Property:

• Vapor Pressure: 2.87E-06mmHg at 25°C
• Boiling Point: 363.4°Cat760mmHg
• Flash Point: 173.6°C
• Density: 0.942g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 12
• Exact Mass: 243.219829168
• Heavy Atom Count: 17
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCC(C(=O)O)N

Technology Process of 2-Aminotetradecanoic acid

There total 10 articles about 2-Aminotetradecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-aminotetradecanonitrile → 2‐aminotetradecanoic acid (7145-63-3)

Guidance literature:

With hydrogenchloride; at 40 ℃; for 6h;

DOI:10.1016/j.tet.2017.03.023

Reference yield:

sodium cyanide (773837-37-9) + tridecanal (10486-19-8) → 2‐aminotetradecanoic acid (7145-63-3)

Guidance literature:

sodium cyanide; tridecanal; With ammonium chloride; In 1,2-dimethoxyethane; water; at 50 ℃; for 20h; Autoclave;

With hydrogenchloride; at 40 ℃; for 6h;

DOI:10.1016/j.tet.2017.03.023

Reference yield:

1-dodecylbromide (143-15-7) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → 2‐aminotetradecanoic acid (7145-63-3)

Guidance literature:

1-dodecylbromide; 2-acetylaminomalonic acid diethyl ester; With ethanol; sodium; In ethanol; for 24h; Heating;

With hydrogenchloride; In N,N-dimethyl-formamide; for 24h; Further stages.; Heating;

DOI:10.1021/ja9934605

upstream raw materials:

2-bromomyristic acid

diethyl α-acetamido-α-dodecyl malonate

1-dodecylbromide

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

C₁₄H₂₉NO₂*C₁₈H₃₇N₅O₉

2-(tert-butoxycarbonylamino)-D,L-tetradecanoic acid

Refernces

• 1、 Parekh, Harendra S.,Marano, Robert J.,Rakoczy, Elizabeth P.,Blanchfield, Joanne,Toth, Istvan. "Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition". . p. 4775 - 4780. Retrieved 2007/10/03.
• 2、 Culbertson, Sean M.,Porter, Ned A.. "Unsymmetrical azo initiators increase efficiency of radical generation in aqueous dispersions, liposomal membranes, and lipoproteins". . p. 4032 - 4038. Retrieved 2007/10/03.