Technology Process of Diquafosol
There total 28 articles about Diquafosol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C9H13N2O9P*C12H27N;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide; acetonitrile;
at 20 ℃;
for 2h;
Inert atmosphere;
UTP-3Na;
With
hydrogenchloride; gadolinium(III) chloride hexahydrate;
In
water; N,N-dimethyl-formamide; acetonitrile;
at 0 - 15 ℃;
pH=4.1;
- Guidance literature:
-
C9H15N2O15P3*C12H27N;
With
diisopropyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
uridine 5′-monophosphate tributylammonium salt;
With
water; magnesium chloride;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 1h;
Product distribution / selectivity;
- Guidance literature:
-
With
calcium(II) chloride dihydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
water;
at 10 ℃;
for 4.5h;
Reagent/catalyst;
Temperature;
