Uridine Monophosphate

Base Information

• Chemical Name: Uridine Monophosphate
• CAS No.: 58-97-9
• Deprecated CAS: 53624-79-6,81795-92-8
• Molecular Formula: C9H13 N2 O9 P
• Molecular Weight: 324.184
• Hs Code.: 2934999090
• European Community (EC) Number: 200-408-0
• UNII: E2OU15WN0N
• DSSTox Substance ID: DTXSID20883211
• Nikkaji Number: J4.594B
• Wikipedia: Uridine_monophosphate
• Wikidata: Q27074278
• Metabolomics Workbench ID: 37182
• ChEMBL ID: CHEMBL214393
• Mol file: 58-97-9.mol

Synonyms:5'-Monophosphate, Uridine;Acid, Uridylic;Acids, Uridylic;Monophosphate, Uridine;UMP;Uridine 5' Monophosphate;Uridine 5'-Monophosphate;Uridine Monophosphate;Uridylic Acid;Uridylic Acids

Chemical Property of Uridine Monophosphate

Chemical Property:

• Melting Point: 202°C (rough estimate)
• Boiling Point: °Cat760mmHg
• PKA: pK1:6.63 (25°C)
• Flash Point: °C
• PSA: 181.12000
• Density: 1.865 g/cm³
• LogP: -2.73490
• Storage Temp.: −20°C
• Solubility.: H2O: soluble50mg/mL, clear, colorless
• XLogP3: -3.6
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 324.03586699
• Heavy Atom Count: 21
• Complexity: 517

Purity/Quality:

99%, ^*data from raw suppliers

Uridine 5′-monophosphate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Nucleic Acids and Derivatives
• Canonical SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
• Isomeric SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
• Recent EU Clinical Trials: Prospective Pilot Study of the treatment of compression of median nerve neuropathy with Nucleo CMP Forte?.
• Description: Uridine 5'-monophosphateis a nucleotide that is synthesized from uridine. Uridine 5'-monophosphate has been shown to have anticancer activity in vitro and in vivo, as well as antiviral activity against herpes viruses. It is also used in foods such as infant formula to as a method of increasing uridine levels in blood.
• Uses: Uridine 5''-Monophosphate is a nucleotide used as monomer in RNA. It is used in foods such as infant formula to as a method of increasing uridine levels in blood. Biochemical research.

Technology Process of Uridine Monophosphate

There total 76 articles about Uridine Monophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

yeast RNA → cytidine monophosphate (63-37-6,30811-80-4) + 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Guanosine 5'-monophosphate (85-32-5)

Guidance literature:

With barley roots 5'-phosphodiesterase; at 70 ℃; for 0.5h; pH=5; aq. acetate buffer; Enzymatic reaction;

Reference yield:

A(2'p5'A)3'p5'U → 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With SVP (1 unit); In water; at 37 ℃; for 12h; Product distribution; HPLC analysis; no reaction with RNaseT₂ or spleen phosphodiesterase;

DOI:10.1016/0040-4020(95)00590-5

Reference yield:

A(2'p5'G)3'p5'U → 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Guanosine 5'-monophosphate (85-32-5)

Guidance literature:

With SVP (1 unit); In water; at 37 ℃; for 12h; Product distribution; HPLC analysis; no reaction with RNaseT₂ or spleen phosphodiesterase;

DOI:10.1016/0040-4020(95)00590-5

upstream raw materials:

2',3'-O-isopropylideneuridine

orotic acid

(R)-2',3'-O-benzylideneuridine

5-phosphoribosyl-1-pyrophosphate

Downstream raw materials:

5-Brom-uridin-5'-phosphat

uridine 3',5'-cyclic monophosphate

UDP

UTP

Refernces

• 1、 Fujio,Akihiko. "Enzymatic production of pyrimidine nucleotides using corynebacterium ammoniagenes cells and recombinant Escherichia coli cells: Enzymatic production of CDP-choline from orotic acid and choline chloride (Part I)". . p. 956 - 959. Retrieved 1997.
• 2、 Kang, Minhee,Doddapaneni, Kiran,Sarni, Samantha,Heppner, Zach,Wysocki, Vicki,Wu, Zhengrong. "Solution structure of the nucleotide hydrolase BlsM: Implication of its substrate specificity". . p. 1760 - 1773. Retrieved 2020/07/27.
• 3、 Nakajima, Kazuki,Kizuka, Yasuhiko,Yamaguchi, Yoshiki,Hirabayashi, Yoshio,Takahashi, Kazuo,Yuzawa, Yukio,Taniguchi, Naoyuki. "Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs". . p. 401 - 407. Retrieved 2017/11/17.