5-Chloronicotinic acid

Base Information

• Chemical Name: 5-Chloronicotinic acid
• CAS No.: 22620-27-5
• Molecular Formula: C6H4ClNO2
• Molecular Weight: 157.556
• Hs Code.: 29333990
• Mol file: 22620-27-5.mol

Synonyms:Nicotinicacid, 5-chloro- (6CI,7CI,8CI);5-Chloro-3-pyridinecarboxylic acid;NSC 63881;

Chemical Property of 5-Chloronicotinic acid

Chemical Property:

• Appearance/Colour: off white powder
• Vapor Pressure: 0.000402mmHg at 25°C
• Melting Point: 169-171 °C
• Refractive Index: 1.59
• Boiling Point: 303.7 °C at 760 mmHg
• PKA: 3.10±0.10(Predicted)
• Flash Point: 137.5 °C
• PSA: 50.19000
• Density: 1.47 g/cm³
• LogP: 1.43320
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

5-Chloronicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.

Technology Process of 5-Chloronicotinic acid

There total 5 articles about 5-Chloronicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-nicotinic acid ethyl ester (20825-98-3) → 5-chloronicotinic acid (22620-27-5)

Guidance literature:

With sodium hydroxide; water; at 60 ℃; for 1h;

Reference yield:

→ 5-chloronicotinic acid (22620-27-5)

Guidance literature:

With hydrogenchloride; copper(l) chloride;

DOI:10.1021/ja01187a020

Reference yield:

→ 5-chloronicotinic acid (22620-27-5)

Guidance literature:

With thionyl chloride; at 130 ℃; im Rohr und nachfolgend Zersetzen mit Wasser;

upstream raw materials:

5,6-dichloronicotinic acid

5-chloro-nicotinic acid ethyl ester

Downstream raw materials:

5-aminonicotinic acid

(5-chloro-pyridin-3-yl)-methanol

5-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide

methyl 5-chloropyridine-3-carboxylate

Refernces