5-Aminonicotinic acid

Base Information

• Chemical Name: 5-Aminonicotinic acid
• CAS No.: 24242-19-1
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 29333990
• Mol file: 24242-19-1.mol

Synonyms:5-aminopyridine-3-carboxylate;

Chemical Property of 5-Aminonicotinic acid

Chemical Property:

• Appearance/Colour: Off-white crystal
• Vapor Pressure: 2.21E-08mmHg at 25°C
• Melting Point: 293 °C
• Refractive Index: 1.5100 (estimate)
• Boiling Point: 436.2 °C at 760 mmHg
• PKA: 2.36±0.10(Predicted)
• Flash Point: 217.6 °C
• PSA: 76.21000
• Density: 1.417 g/cm³
• LogP: 0.94320
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%, ^*data from raw suppliers

5-Aminonicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 36/37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Aminonicotinic acid is used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents.

Technology Process of 5-Aminonicotinic acid

There total 6 articles about 5-Aminonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-3-pyridinecarboxylic acid (20826-04-4) → 5-aminonicotinic acid (24242-19-1)

Guidance literature:

5-bromo-3-pyridinecarboxylic acid; With copper(ll) sulfate pentahydrate; ammonia; In water; at 170 - 180 ℃; for 19h; Autoclave;

In water; pH=4 - 5; Acidic aq. solution;

DOI:10.1016/j.bmc.2010.07.018

Reference yield:

nicotinic acid (59-67-6) → 5-aminonicotinic acid (24242-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Erhitzen des Reaktionsprodukts mit Brom auf 150-170grad und Behandeln des Reaktionsgemisches mit H₂O bei pH 3

2: aqueous NH₃; CuSO₄ / 180 °C

With ammonium hydroxide; thionyl chloride; copper(II) sulfate;

DOI:10.1021/ja01187a020

Reference yield:

5-chloronicotinic acid (22620-27-5) → 5-aminonicotinic acid (24242-19-1)

Guidance literature:

With ammonia; copper(II) oxide; at 180 ℃; im Rohr;

upstream raw materials:

5-chloronicotinic acid

5-bromo-3-pyridinecarboxylic acid

5-amino-nicotinic acid methyl ester

ammonia

Downstream raw materials:

pyridin-3-ylamine

5-hydroxynicotinic acid

5-aminonicotinic acid ethyl ester

5-amino-N-(3-{(1S)-1-[(6-chloropyrazin-2-yl)amino]ethyl}phenyl)nicotinamide

Refernces

• 1、 Umezawa, Naoki,Matsumoto, Nobuyoshi,Iwama, Shinsuke,Kato, Nobuki,Higuchi, Tsunehiko. "Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase". experimental part. p. 6340 - 6350. Retrieved 2010/10/04.
• 2、 -. "PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES". Page 50-51. . Retrieved 2010/02/05.