Ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: Ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS No.: 51787-77-0
• Molecular Formula: C10H17 N O4
• Molecular Weight: 215.249
• Hs Code.: 2934999090
• European Community (EC) Number: 257-418-3
• DSSTox Substance ID: DTXSID90199710
• Nikkaji Number: J294.910E
• Wikidata: Q83072653
• Mol file: 51787-77-0.mol

Synonyms:51787-77-0;ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate;EINECS 257-418-3;Ethyl 1,4-dioxa-8-azaspiro(4.5)decane-8-carboxylate;DTXSID90199710;STK471626;AKOS003374576;1,4-Dioxa-8-azaspiro[4.5]decane-8-carboxylic acid ethyl ester;1,4-Dioxa-8-azaspiro(4.5)decane-8-carboxylic acid, ethyl ester

Chemical Property of Ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property:

• Vapor Pressure: 0.000456mmHg at 25°C
• Boiling Point: 314.8°C at 760 mmHg
• Flash Point: 144.2°C
• PSA: 48.00000
• Density: 1.19g/cm³
• LogP: 0.91970
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 215.11575802
• Heavy Atom Count: 15
• Complexity: 228

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-1,4-DIOXA-8-AZASPIRO[4.5]DECANE-8-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)N1CCC2(CC1)OCCO2

Technology Process of Ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate

There total 5 articles about Ethyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 4,4-ethylenedioxy-piperidine (177-11-7) → 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ethyl ester (51787-77-0)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)79248-3

Reference yield:

1-methylpiperidin-4-one hydrochloride (34737-83-2) → 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ethyl ester (51787-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / benzene

2: benzene / Heating

With toluene-4-sulfonic acid; In benzene;

DOI:10.1135/cccc19733879

Reference yield:

1-benzyl-4-piperidone hydrochloride (20821-52-7) → 1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid ethyl ester (51787-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: benzene / Heating

In benzene;

DOI:10.1135/cccc19733879

upstream raw materials:

8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan

chloroformic acid ethyl ester

8-benzyl-1,4-dioxa-8-azaspiro[4.5]decane

4,4-ethylenedioxy-piperidine

Downstream raw materials:

4,4-ethylenedioxy-piperidine

N-ethoxycarbonyl-4-piperidone

Refernces

• 1、 Sindelar,Rajsner,Cervena,et al.. "Neurotropic and psychotropic agents. LXVII. 1 [4,4 bis(4 fluorophenyl)butyl] 4 hydroxy 4 (3 trifluoromethyl 4 chlorophenyl)piperidine and related compounds: new synthetic approaches". . p. 3879 - 3901. Retrieved 2007/10/04.