1-Methyl-4-piperidinol hydrochloride

Base Information

• Chemical Name: 1-Methyl-4-piperidinol hydrochloride
• CAS No.: 34737-83-2
• Molecular Formula: C6H11NO.ClH
• Molecular Weight: 149.62
• Hs Code.: 2933399090
• Mol file: 34737-83-2.mol

Synonyms:4-Piperidinone,1-methyl-, hydrochloride (9CI);N-Methyl-4-piperidinone hydrochloride;N-Methyl-4-piperidone hydrochloride;

Chemical Property of 1-Methyl-4-piperidinol hydrochloride

Chemical Property:

• Melting Point: 95 °C
• Boiling Point: 236.8 °C at 760 mmHg
• Flash Point: 97 °C
• PSA: 23.47000
• LogP: 0.81280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

1-Methyl-4-piperidone hydrochloride 99 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-4-piperidinol hydrochloride

There total 6 articles about 1-Methyl-4-piperidinol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester (13221-89-1,56026-45-0) → 1-methylpiperidin-4-one hydrochloride (34737-83-2)

Guidance literature:

With hydrogenchloride; In water; for 5.16667h; Reflux;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → 1-methylpiperidin-4-one hydrochloride (34737-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrochloric acid; water / unter vermindertem Druck

2: 120 °C / 2 Torr

With hydrogenchloride; water;

DOI:10.1021/jo01085a012

Reference yield:

→ 1-methylpiperidin-4-one hydrochloride (34737-83-2)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

4,4-Dihydroxy-1-methylpiperidinium-chlorid

1-Methyl-4-piperidone

methylimine-N,N-dipropionate methyl ester

1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester

Downstream raw materials:

2-Methyl-5-phenyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indol

8-Methyl-1,4-dioxa-8-azoniaspiro<4.5>decan

4-cyano-4-hydroxy-1-methylpiperidine

mebhydrolin

Refernces

• 1、 -. "Lightening Agents and/or Dyes that Contain Aldehyde(s)". . . Retrieved 2010/12/29.
• 2、 -. "Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties". Page 33. . Retrieved 2010/01/31.