methyl 3-(2-methoxycarbonylethylamino)propanoate

Base Information

• Chemical Name: methyl 3-(2-methoxycarbonylethylamino)propanoate
• CAS No.: 3518-85-2
• Molecular Formula: C8H15 N O4
• Molecular Weight: 189.211
• Hs Code.: 2922499990
• Mol file: 3518-85-2.mol

Synonyms:Propionicacid, 3,3'-iminodi-, dimethyl ester (6CI,7CI,8CI); Dimethyl3,3'-azanediyldipropanoate; Dimethyl iminodipropionate;N,N-Bis(2-methoxycarbonylethyl)amine; NSC 20924

Chemical Property of methyl 3-(2-methoxycarbonylethylamino)propanoate

Chemical Property:

• Melting Point: 7-8 °C
• Boiling Point: 257.4°Cat760mmHg
• PKA: 7.65±0.19(Predicted)
• Flash Point: 109.5°C
• PSA: 64.63000
• Density: 1.072g/cm³
• LogP: 0.09310

Purity/Quality:

99% ^*data from raw suppliers

methylN-(3-methoxy-3-oxopropyl)-β-alaninatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(2-methoxycarbonylethylamino)propanoate

There total 9 articles about methyl 3-(2-methoxycarbonylethylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

bis(2-methoxycarbonylethyl)benzylamine (793-19-1) → methylimine-N,N-dipropionate methyl ester (3518-85-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 20h; under 760.051 Torr;

Reference yield: 58.0%

methyl 3-((2-(methoxycarbonyl)ethyl)amino)propanoate hydrochloride (67363-88-6) → methylimine-N,N-dipropionate methyl ester (3518-85-2)

Guidance literature:

With potassium carbonate; In water;

DOI:10.1007/s11172-009-0280-3

Reference yield: 28.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methylimine-N,N-dipropionate methyl ester (3518-85-2)

Guidance literature:

With ammonia; In methanol; 1.) room temperature, 30 min, 2.) reflux, 15 h;

DOI:10.1021/ja00535a043

upstream raw materials:

acrylic acid methyl ester

ammonia

methyl 3-((2-(methoxycarbonyl)ethyl)amino)propanoate hydrochloride

Methyl 3-bromopropionate

Downstream raw materials:

1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester

1-methylpiperidin-4-one hydrochloride

C₃₆H₃₄N₂O₈

C₁₆H₂₄N₃O₁₁P

Refernces

• 1、 Hermosilla, Pablo,López, Pablo,García-Ordunìa, Pilar,Lahoz, Fernando J.,Polo, Víctor,Casado, Miguel A.. "Amido Complexes of Iridium with a PNP Pincer Ligand: Reactivity toward Alkynes and Hydroamination Catalysis". . p. 2618 - 2629. Retrieved 2018/08/21.
• 2、 -. "RECYCLABLE CATALYSTS FOR CHLORINATION OF ORGANIC ACIDS AND ALCOHOLS". Paragraph 0080-0082. . Retrieved 2017/10/10.