Trimethylarsine

Base Information

• Chemical Name: Trimethylarsine
• CAS No.: 593-88-4
• Molecular Formula: C3H9 As
• Molecular Weight: 120.026
• European Community (EC) Number: 209-815-8
• UNII: MQ83UQ8A1Q
• DSSTox Substance ID: DTXSID4073203
• Nikkaji Number: J459F
• Wikipedia: Trimethylarsine
• Wikidata: Q421500
• Metabolomics Workbench ID: 54025
• Mol file: 593-88-4.mol

Synonyms:trimethylarsine

Chemical Property of Trimethylarsine

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 265mmHg at 25°C
• Melting Point: -87,3ºC
• Boiling Point: 53.8ºC at 760 mmHg
• Flash Point: 100ºC
• PSA: 0.00000
• Density: g/cm³
• LogP: 1.37060
• Storage Temp.: Refrigerator, under inert atmosphere
• Sensitive.: air sensitive
• Solubility.: Benzene
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 119.992020
• Heavy Atom Count: 4
• Complexity: 8

Purity/Quality:

99%, ^*data from raw suppliers

Trimethylarsine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): TNT
• Hazard Codes: T,N,F
• Statements: 11-23/25-50/53-14/15
• Safety Statements: 3/7-9-23-45-61-60-28-20/21

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Metals -> Arsenic Compounds, Organic
• Canonical SMILES: C[As](C)C
• Uses: Trimethylarsine is an environmental pollutant found in lake sediment. Trimethylarsine is toxic to mammalian cells.

Technology Process of Trimethylarsine

There total 41 articles about Trimethylarsine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

trimethylaluminum (75-24-1) → trimethylarsine (593-88-4)

Guidance literature:

With arsenic(III) trioxide; In dibutyl ether; at 80 - 130 ℃; for 0.416667h;

DOI:10.1007/BF01457800

Reference yield: 90.5%

trimethylaluminum (75-24-1) → trimethylarsine (593-88-4)

Guidance literature:

With arsenic(III) trioxide; In 1,4-dioxane; 1.) 100 deg C, 35 min, 2.) reflux, 2 h;

Reference yield:

bis-{dimethylarsenic}-oxide (503-80-0) + dihydrogen peroxide (7722-84-1) → trimethylarsine (593-88-4) + methylarsine oxide (593-58-8) + Dimethylarsinic acid (75-60-5)

Guidance literature:

Produkt 5: Trimethylarsinoxyd; Produkt 6: Methylarsinsaeure;

upstream raw materials:

methanol

methyl magnesium iodide

dimethyliodoarsine

2-arsono-propionic acid

Downstream raw materials:

iodomethyl-trimethyl-arsonium; iodide

Trimethyl-arsinselenid

trimethylarsine oxide

Dimethylarsinic acid

Refernces

• 1、 Allred,Hensley. "". . p. 43,44. Retrieved 1961.
• 2、 Miller,Muetterties. "". . p. 1033,1034, 1036, 1038. Retrieved 1964.
• 3、 Pichereau, Vianney,Cosquer, Anne,Gaumont, Annie-Claude,Bernard, Theophile. "Synthesis of trimethylated phosphonium and arsonium analogues of the osmoprotectant glycine betaine; contrasted biological activities in two bacterial species". . p. 2893 - 2896. Retrieved 1997.
• 4、 Marschner, Karel,Musil, Stanislav,Dědina, Ji?í. "Demethylation of Methylated Arsenic Species during Generation of Arsanes with Tetrahydridoborate(1-) in Acidic Media". . p. 6366 - 6373. Retrieved 2016/07/06.
• 5、 Yablokov,Mitrofanova,Krasnodubskaya,Dozorov,Devyat'yarov. "Synthesis of Trimethylarsenic". . p. 570 - 571. Retrieved 2007/10/03.