1,2,3,5-TETRAMETHOXYBENZENE

Base Information

• Chemical Name: 1,2,3,5-TETRAMETHOXYBENZENE
• CAS No.: 5333-45-9
• Molecular Formula: C10H14 O4
• Molecular Weight: 198.219
• Hs Code.: 2909309090
• Mol file: 5333-45-9.mol

Synonyms:1,2,3,5-Tetramethoxybenzene;NSC 2408

Chemical Property of 1,2,3,5-TETRAMETHOXYBENZENE

Chemical Property:

• Vapor Pressure: 0.00764mmHg at 25°C
• Melting Point: 38-42 °C(lit.)
• Boiling Point: 277.4°Cat760mmHg
• Flash Point: 111.6°C
• PSA: 36.92000
• Density: 1.068g/cm³
• LogP: 1.72100
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

1,2,3,5-Tetramethoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1,2,3,5-TETRAMETHOXYBENZENE

There total 39 articles about 1,2,3,5-TETRAMETHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4,5-trimethoxyphenol (642-71-7) + dimethyl sulfate (77-78-1) → 1,2,3,5-tetramethoxybenzene (5333-45-9)

Guidance literature:

With potassium carbonate; In acetone; Inert atmosphere;

DOI:10.1016/j.tet.2015.02.017

Reference yield: 93.0%

2,6-dimethoxy-1,4-hydroquinone (15233-65-5) + dimethyl sulfate (77-78-1) → 1,2,3,5-tetramethoxybenzene (5333-45-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

Reference yield: 71.0%

methanol (67-56-1) + 5,6,6-trimethoxycyclohexa-2,4-dien-1-one (57197-26-9) → 1,2,3,5-tetramethoxybenzene (5333-45-9)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2015.11.012

upstream raw materials:

2,6-dimethoxy-1,4-hydroquinone

dimethyl sulfate

2,3-dimethoxy-1,6-dihydroxybenzene

2,5-dimethoxyresorcinol

Downstream raw materials:

2-bromo-1,3,4,5-tetramethoxybenzene

1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

1-(2,3,4,6-tetramethoxyphenyl)ethanone

2-Hydroxy-2',3,4,5',6-pentamethoxybenzophenon

Refernces

• 1、 Chittimalla, Santhosh Kumar,Bandi, Chennakesavulu. "Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols". supporting information. p. 15 - 19. Retrieved 2015/12/23.
• 2、 Caldwell, Stuart T.,McPhail, Donald B.,Duthie, Garry G.,Hartley, Richard C.. "Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants". scheme or table. p. 23 - 33. Retrieved 2012/03/07.