2,6-Dimethoxyhydroquinone

Base Information

• Chemical Name: 2,6-Dimethoxyhydroquinone
• CAS No.: 15233-65-5
• Molecular Formula: C8H10O4
• Molecular Weight: 170.165
• Hs Code.: 2909500000
• European Community (EC) Number: 239-282-7
• NSC Number: 49356
• UNII: 9U2C06A3MM
• DSSTox Substance ID: DTXSID40165001
• Nikkaji Number: J49.297C
• Wikidata: Q27273224
• Mol file: 15233-65-5.mol

Synonyms:Hydroquinone,2,6-dimethoxy- (6CI,7CI,8CI);2,6-Dimethoxy-1,4-benzenediol;2,6-Dimethoxy-1,4-dihydroxybenzene;2,6-Dimethoxy-4-hydroxyphenol;2,6-Dimethoxyquinol;3,5-Dimethoxyhydroquinone;NSC49356;

Chemical Property of 2,6-Dimethoxyhydroquinone

Chemical Property:

• Vapor Pressure: 1.82E-05mmHg at 25°C
• Melting Point: 158-162 °C(lit.)
• Refractive Index: 1.559
• Boiling Point: 352.924 °C at 760 mmHg
• PKA: 9.95±0.23(Predicted)
• Flash Point: 167.243 °C
• PSA: 58.92000
• Density: 1.267 g/cm³
• LogP: 1.11500
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 170.05790880
• Heavy Atom Count: 12
• Complexity: 125

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Dimethoxybenzene-1,4-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1O)OC)O
• Uses: 2,6-Dimethoxybenzene-1,4-diol is used in method for preparing modified fraxinol glycoside for sunscreen isolation cream.

Technology Process of 2,6-Dimethoxyhydroquinone

There total 17 articles about 2,6-Dimethoxyhydroquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,6-dimethoxy-p-quinone (530-55-2,26547-64-8) → 2,6-dimethoxy-1,4-hydroquinone (15233-65-5)

Guidance literature:

With sodium dithionite; In water; at 20 ℃; for 3h; Temperature; Solvent;

Reference yield: 90.0%

syringic aldehyde (134-96-3) → formic acid (64-18-6) + 2,6-dimethoxy-1,4-hydroquinone (15233-65-5)

Guidance literature:

syringic aldehyde; With sodium percarbonate; In tetrahydrofuran; water; at 25 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; pH=1; Inert atmosphere;

DOI:10.1039/c5gc01070e

Reference yield: 90.0%

syringic aldehyde (134-96-3) → 2,6-dimethoxy-1,4-hydroquinone (15233-65-5)

Guidance literature:

With dihydrogen peroxide; at 20 ℃; for 1h; Green chemistry;

DOI:10.1039/c5gc01404b

upstream raw materials:

2,6-dimethoxy-p-quinone

3,5-dimethoxy-4-hydroxybenzoic acid

3,5-dimethoxyphenol

(1-Hydroxy-2,6-dimethoxy-4-oxo-cyclohexa-2,5-dienyl)-methoxy-acetic acid ethyl ester

Downstream raw materials:

3,6-dihydroxy-2,4-dimethoxy-deoxybenzoin

3,6-dihydroxy-2,4,4'-trimethoxy-deoxybenzoin

4-ethoxy-3,5-dimethoxy-phenol

3,6-diethoxy-2-hydroxy-4-methoxyacetophenone

Refernces

• 1、 Lin, Sheng,Wang, Sujuan,Liu, Mingtao,Gan, Maoluo,Li, Shuai,Yang, Yongchun,Wang, Yinghong,He, Wenyi,Shi, Jiangong. "Glycosides from the stem bark of Fraxinus sieboldiana". . p. 817 - 823. Retrieved 2007.
• 2、 Agarwal, Rishi G.,Mayer, James M.,Wise, Catherine F.. "Determining Proton-Coupled Standard Potentials and X-H Bond Dissociation Free Energies in Nonaqueous Solvents Using Open-Circuit Potential Measurements". . p. 10681 - 10691. Retrieved 2020.
• 3、 Simonyi et al.. "". . . Retrieved 1977.
• 4、 Zeng, Jijiao,Mills, Matthew J. L.,Simmons, Blake A.,Kent, Michael S.,Sale, Kenneth L.. "Understanding factors controlling depolymerization and polymerization in catalytic degradation of β-ether linked model lignin compounds by versatile peroxidase". . p. 2145 - 2154. Retrieved 2017.
• 5、 -. "Method For Producing Low Molecular Weight Aromatic Lignin-Derived Compounds". Paragraph 0320-0321. . Retrieved 2019/04/08.