(PIPERAZIN-1-YL)(PYRIDIN-2-YL) METHANONE

Base Information

• Chemical Name: (PIPERAZIN-1-YL)(PYRIDIN-2-YL) METHANONE
• CAS No.: 39639-98-0
• Molecular Formula: C10H13 N3 O
• Molecular Weight: 191.233
• Hs Code.: 2933990090
• Mol file: 39639-98-0.mol

Synonyms:Piperazine,1-(2-pyridinylcarbonyl)- (9CI); (Pyridin-2-yl)(piperazin-1-yl)methanone; EGYT1354; N-(2'-Pyridinecarbonyl)piperazine; N-(Pyridin-2-ylcarbonyl)piperazine

Chemical Property of (PIPERAZIN-1-YL)(PYRIDIN-2-YL) METHANONE

Chemical Property:

• Boiling Point: 369oC at 760 mmHg
• Flash Point: 176.9oC
• PSA: 45.23000
• Density: 1.167
• LogP: 0.39370
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Pyridinecarbonyl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (PIPERAZIN-1-YL)(PYRIDIN-2-YL) METHANONE

There total 8 articles about (PIPERAZIN-1-YL)(PYRIDIN-2-YL) METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-Picolinic acid (98-98-6) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → piperazin-1-yl(pyridin-2-yl)methanone (39639-98-0)

Guidance literature:

2-Picolinic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-t-Butoxycarbonylpiperazine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2022.114193

Reference yield:

tert-butyl 4-picolinoylpiperazine-1-carboxylate (389628-28-8) → piperazin-1-yl(pyridin-2-yl)methanone (39639-98-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 48h;

Reference yield:

piperazine (110-85-0) + pyridine-2-carbonyl chloride (29745-44-6) → piperazin-1-yl(pyridin-2-yl)methanone (39639-98-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1007/s00044-019-02398-2

upstream raw materials:

tert-butyl 4-picolinoylpiperazine-1-carboxylate

2-Picolinic acid

piperazine

p-nitrophenyl picolinate

Downstream raw materials:

C₂₅H₂₉F₃N₄O₄

C₂₀H₂₁F₃N₄O₂

(4-{2-(4-Fluoro-phenyl)-2-[(pyridin-2-ylmethyl)-amino]-ethyl}-piperazin-1-yl)-pyridin-2-yl-methanone

{4-[2-(4-Fluoro-phenyl)-2-hydroxy-ethyl]-piperazin-1-yl}-pyridin-2-yl-methanone

Refernces

• 1、 Bojarski, Andrzej J.,Dehaen, Wim,Janousek, Jiri,Juza, Radomir,Karasova, Jana Zdarova,Kobrlova, Tereza,Korabecny, Jan,Kubacka, Monika,Mezeiova, Eva,Mogilski, Szczepan,Musilek, Kamil,Pejchal, Jaroslav,Petrasek, Tomas,Prchal, Lukas,Randakova, Alena,Satala, Grzegorz,Soukup, Ondrej,Stark, Holger,Stefkova-Mazochova, Kristyna,Svozil, Daniel,Vlcek, Premysl,Vojtechova, Iveta. "Novel D2/5-HT receptor modulators related to cariprazine with potential implication to schizophrenia treatment". . . Retrieved 2022/02/17.
• 2、 Xu, Yiming,Liang, Pengyun,Rashid, Haroon ur,Wu, Lichuan,Xie, Peng,Wang, Haodong,Zhang, Shuyan,Wang, Lisheng,Jiang, Jun. "Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents". . p. 1618 - 1627. Retrieved 2019/07/29.