5,8-Dihydro-1-naphthol

Base Information

• Chemical Name: 5,8-Dihydro-1-naphthol
• CAS No.: 27673-48-9
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Hs Code.: 2906299090
• European Community (EC) Number: 248-596-3
• NSC Number: 125584
• DSSTox Substance ID: DTXSID30182040
• Nikkaji Number: J250.569J
• Wikidata: Q72465725
• Mol file: 27673-48-9.mol

Synonyms:5,8-Dihydro-1-naphthol;27673-48-9;5,8-dihydronaphthalen-1-ol;1-Naphthalenol, 5,8-dihydro-;5,8-Dihydro-naphthalen-1-ol;5,8-Dihydronaphthol;5,8-Dihydro-1-naphthalenol;NSC 125584;EINECS 248-596-3;MFCD00128247;5,8-Dihydro-1-naphthol (90per cent);5-Hydroxy-1,4-dihydronaphthalene;5,8-Dihydro-1-naphthol (90%);5,8-Dihydronaphtol;NSC125584;58-Dihydro-1-naphthol;5 8-Dihydro-1-naphthol;5 8-Dihydronaphthalen-1-ol;SCHEMBL506663;1-Naftalenol, 5,8-dihidro-;5,8-Dihydro-1-naphthalenol #;DTXSID30182040;5-Hydroxy-1 4-dihydronaphthalene;1-Naphthol58-dihydro-(6CI8CI);5,8-Dihydro-1-naphthol, AldrichCPR;AKOS006272429;NSC-125584;1-Naphthol 5 8-dihydro-(6CI 8CI);1-naftol, 5,8-dihidro-(6CI, 8CI);AC-15143;AMY202100064;CS-0450577;FT-0619860;EN300-171224;A819152;SR-01000944967;SR-01000944967-1;W-110707

Chemical Property of 5,8-Dihydro-1-naphthol

Chemical Property:

• Appearance/Colour: Dark brown solid
• Vapor Pressure: 0.00579mmHg at 25°C
• Melting Point: 56-60 °C
• Refractive Index: 1.612
• Boiling Point: 264.839 °C at 760 mmHg
• PKA: 10.18±0.20(Predicted)
• Flash Point: 119 °C
• PSA: 20.23000
• Density: 1.142 g/cm³
• LogP: 2.04700
• Storage Temp.: Amber Vial, -20°C Freezer
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.073164938
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

5,8-Dihydro-1-naphthol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-51/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C=CCC2=C1C=CC=C2O
• Uses: Nadolol intermediate.

Technology Process of 5,8-Dihydro-1-naphthol

There total 17 articles about 5,8-Dihydro-1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

α-naphthol (90-15-3) → 5,8-dihydro-1-naphthol (27673-48-9)

Guidance literature:

With ammonia; lithium; In ethanol; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.11.012

Reference yield: 50.0%

α-naphthol (90-15-3) → 5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) + 5,8-dihydro-1-naphthol (27673-48-9)

Guidance literature:

With potassium hydroxide; samarium diiodide; In tetrahydrofuran; water; for 0.0833333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)73141-8

Reference yield: 44.0%

α-naphthol (90-15-3) → 5,6-dihydro-1-naphthol (1429-22-7) + 5,6,7,8-Tetrahydronaphthalen-1-ol (529-35-1) + 5,8-dihydro-1-naphthol (27673-48-9)

Guidance literature:

With potassium hydroxide; samarium diiodide; In tetrahydrofuran; water; for 0.0166667h; Ambient temperature;

DOI:10.1016/S0040-4039(00)73141-8

upstream raw materials:

α-naphthol

1-amino-5,8-dihydronaphthalene

tert-Amyl alcohol

ammonia

Downstream raw materials:

5,6-dihydro-1-naphthol

7,8-dihydro-naphthalen-2-ol

1,4-dihydro-5-methoxynaphthalene

2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene

Refernces

• 1、 Bajaj, Priyanka,Sreenilayam, Gopeekrishnan,Tyagi, Vikas,Fasan, Rudi. "Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity". supporting information. p. 16110 - 16114. Retrieved 2016/12/26.
• 2、 Nador, Fabiana,Moglie, Yanina,Vitale, Cristian,Yus, Miguel,Alonso, Francisco,Radivoy, Gabriel. "Reduction of polycyclic aromatic hydrocarbons promoted by cobalt or manganese nanoparticles". experimental part. p. 4318 - 4325. Retrieved 2010/07/09.