2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene
• CAS No.: 143325-87-5
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 143325-87-5.mol

Synonyms:

Chemical Property of 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene

There total 10 articles about 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-hydroxy-2-tetralone (35697-10-0) → 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene (143325-87-5,35697-11-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.011

Reference yield:

→ 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene (143325-87-5,35697-11-1)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01544a073

Reference yield:

5,8-dihydro-1-naphthol (27673-48-9) → 2,5-dihydroxy-1,2,3,4-tetrahydronaphthalene (143325-87-5,35697-11-1)

Guidance literature:

Multistep reaction; (i) BH₃, THF, (ii) H₂O₂, aq. NaOH;

DOI:10.1021/jm00207a014

upstream raw materials:

8-methoxy-1,2,3,4-tetrahydro-2-naphthol

2,3-epoxy-5-acetoxy-1,2,3,4-tetrahydronaphthalene

5,8-dihydro-1-naphthol

1,2,3,4-tetrahydro-2,8-naphthalenediol

Downstream raw materials:

5-benzyloxy-2-tetralol

Refernces

• 1、 Bonomi, Paolo,Cairoli, Paola,Ubiali, Daniela,Morelli, Carlo F.,Filice, Marco,Nieto, Ines,Pregnolato, Massimo,Manitto, Paolo,Terreni, Marco,Speranza, Giovanna. "Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases". experimental part. p. 467 - 472. Retrieved 2009/09/06.
• 2、 Condon,Cimarusti,Fox,Narayanan,Reid,Sundeen,Hauck. "Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols". . p. 913 - 922. Retrieved 2007/10/06.