N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide

Base Information

• Chemical Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide
• CAS No.: 33016-44-3
• Molecular Formula: C18H28 N2 O3
• Molecular Weight: 320.4265
• Mol file: 33016-44-3.mol

Synonyms:4-Piperidineacetamide,N-(3,4-dimethoxyphenethyl)-1-methyl- (8CI); N-(3,4-Dimethoxyphenethyl)-a-(1-methyl-4-piperidyl)acetamide; NSC 351564

Chemical Property of N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide

Chemical Property:

• Vapor Pressure: 4.36E-10mmHg at 25°C
• Boiling Point: 498.9°Cat760mmHg
• Flash Point: 255.5°C
• Density: 1.058g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide

There total 3 articles about N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1-methylpiperidin-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1-methyl-[4]piperidyl)-acetic acid ethyl ester (67686-05-9) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-(3,4-dimethoxy-phenethyl)-2-(1-methyl-piperidin-4-yl)-acetamide (33016-44-3)

Guidance literature:

With 2-hydroxypyridin;

DOI:10.1002/ardp.19843171206

Reference yield:

1-Methyl-4-piperidone (1445-73-4) → N-(3,4-dimethoxy-phenethyl)-2-(1-methyl-piperidin-4-yl)-acetamide (33016-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) HCl, H₂ / 2.) 10percent Pd/C / 1.) 1,2-dimethoxyethane, 30 deg C, 4 h, 2.) ethanol

2: 77 percent / 2-hydroxypyridine

With 2-hydroxypyridin; hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal;

DOI:10.1002/ardp.19843171206

Reference yield:

→ N-(3,4-dimethoxy-phenethyl)-2-(1-methyl-piperidin-4-yl)-acetamide (33016-44-3)

Guidance literature:

4-(1-Methyl)-piperidylessigsaeuremethylester (6), Homoveratrylamin (8);

DOI:10.1021/jm00291a029

upstream raw materials:

(1-methyl-[4]piperidyl)-acetic acid ethyl ester

2-(3,4-dimethoxyphenyl)-ethylamine

1-Methyl-4-piperidone

Refernces