Methyl 4-methoxyphenylacetate

Base Information

• Chemical Name: Methyl 4-methoxyphenylacetate
• CAS No.: 23786-14-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 29189900
• European Community (EC) Number: 245-886-1
• UNII: CCD9T5HQ7M
• DSSTox Substance ID: DTXSID80178473
• Nikkaji Number: J31.473K
• Wikidata: Q63396574
• Metabolomics Workbench ID: 134272
• ChEMBL ID: CHEMBL445203
• Mol file: 23786-14-3.mol

Synonyms:Methyl 4-methoxyphenylacetate;23786-14-3;methyl 2-(4-methoxyphenyl)acetate;Methyl (4-methoxyphenyl)acetate;Benzeneacetic acid, 4-methoxy-, methyl ester;4-Methoxyphenylacetic Acid Methyl Ester;(4-METHOXY-PHENYL)-ACETIC ACID METHYL ESTER;Methyl 2-(p-methoxyphenyl)acetate;Methyl 4-anisoleacetate;CCD9T5HQ7M;Methyl (p-methoxyphenyl)acetate;Acetic acid, (p-methoxyphenyl)-, methyl ester;EINECS 245-886-1;MFCD00008454;(4-Methoxyphenyl)acetic acid methyl ester;Methyl 4-methoxybenzeneacetate;Methyl Para Methoxyl Phenylacetate;UNII-CCD9T5HQ7M;methyl p-methoxyphenylacetate;methyl p-methoxy-phenylacetate;SCHEMBL313139;CHEMBL445203;DTXSID80178473;4-Methoxybenzeneacetic acid methyl;Methyl 4-methoxyphenylacetate, 97%;STL507838;AKOS000295888;p-Methoxyphenylacetic acid methyl ester;4-Methoxybenzeneacetic acid methyl ester;4-methoxy-phenylacetic acid methyl ester;AS-38064;SY048791;Benzeneacetic acid,4-methoxy-,methyl ester;Phenylacetic acid, 4-methoxy, methyl ester;CS-0130330;FT-0628649;M1330;EN300-1717720;A816904;J-015210;Q63396574

Chemical Property of Methyl 4-methoxyphenylacetate

Chemical Property:

• Appearance/Colour: clear colorless to yellow liquid
• Vapor Pressure: 0.000151mmHg at 25°C
• Refractive Index: n20/D 1.516(lit.)
• Boiling Point: 264 °C at 760 mmHg
• Flash Point: 100.4 °C
• PSA: 35.53000
• Density: 1.083 g/cm³
• LogP: 1.41070
• Storage Temp.: Flammables area
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 4-methoxyphenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:Flammable.
• Hazard Codes: R10:Flammable.
• Statements: 10
• Safety Statements: 16-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)OC
• Uses: Methyl 4-methoxyphenylacetate was used in the synthesis of 7,8-dihydroxy-2-(4′-hydroxybenzyl)-4H-1-benzopyran-4-one.

Technology Process of Methyl 4-methoxyphenylacetate

There total 56 articles about Methyl 4-methoxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-Methoxyphenylacetic acid (104-01-8) → 4-methoxy-phenyl acetic acid methyl ester (23786-14-3)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

DOI:10.1016/S0968-0896(03)00220-7

Reference yield: 100.0%

4-Methoxyphenylacetic acid (104-01-8) + methyl iodide (74-88-4) → 4-methoxy-phenyl acetic acid methyl ester (23786-14-3)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃;

DOI:10.1002/adsc.201901343

Reference yield: 99.0%

methanol (67-56-1) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 4-methoxy-phenyl acetic acid methyl ester (23786-14-3)

Guidance literature:

With sulfuric acid; trimethyl orthoformate; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2007.02.129

upstream raw materials:

2-diazo-1-(4-methoxyphenyl)ethanone

silver benzoate

4-hydroxyphenylacetate

methyl iodide

Downstream raw materials:

(4-methoxy-phenyl)-acetic acid-(4-benzyloxy-3-methoxy-phenethylamide)

4-Methoxyphenylacetic acid

2-(4-methoxyphenyl)acetamide

2,5-dihydroxy-3,6-bis-(4-methoxy-phenyl)-[1,4]benzoquinone

Refernces

• 1、 Jiang, Jun,Zhang, Xinzhi,Zhang, Yangyang,Zhao, Jincheng. "B(C6F5)3-catalyzed O-H insertion reactions of diazoalkanes with phosphinic acids". supporting information. p. 5772 - 5776. Retrieved 2021/07/12.
• 2、 Coles, Simon J.,Hareram, Mishra Deepak,Harnedy, James,Morrill, Louis C.,Tizzard, Graham J.. "Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides". supporting information. p. 12643 - 12646. Retrieved 2021/12/07.