2-(4-Methoxyphenyl)acetamide

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)acetamide
• CAS No.: 6343-93-7
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• European Community (EC) Number: 228-745-9
• NSC Number: 49779
• UNII: RDT39HU3CZ
• DSSTox Substance ID: DTXSID70979618
• Nikkaji Number: J206.953I
• Wikidata: Q27097950
• Metabolomics Workbench ID: 151883
• ChEMBL ID: CHEMBL157604
• Mol file: 6343-93-7.mol

Synonyms:2-(4-Methoxyphenyl)acetamide;6343-93-7;4-Methoxyphenylacetamide;p-Methoxyphenylacetamide;Benzeneacetamide, 4-methoxy-;4-Methoxyphenoxyphenylacetamide;CHEMBL157604;MFCD00017144;NSC-49779;NSC49779;4-methoxyphe-nylacetamide;SCHEMBL1067193;2-(4-Methoxy-phenyl)-acetamide;DTXSID70979618;CH3O(C6H4)CH2C(O)NH2;HMS3604M11;2-(4-Methoxyphenyl)ethanimidic acid;BDBM50226183;AKOS005206992;DB08767;SB76082;(3-NITRO-BENZOYLAMINO)-ACETICACID;AS-38063;CS-0150360;FT-0618951;EN300-7398160;A834382;Q27097950;Z33546648;ZHZ

Chemical Property of 2-(4-Methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 3.29E-05mmHg at 25°C
• Melting Point: 182-184°C
• Boiling Point: 354.7°C at 760 mmHg
• PKA: 16.37±0.40(Predicted)
• Flash Point: 201.3°C
• PSA: 52.32000
• Density: 1.123g/cm³
• LogP: 1.42330
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxyphenylacetamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(=O)N

Technology Process of 2-(4-Methoxyphenyl)acetamide

There total 16 articles about 2-(4-Methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-methoxybenzylnitrile (104-47-2) → 2-(4-methoxyphenyl)acetamide (6343-93-7)

Guidance literature:

With cis-[Mn(2,6-bis(di-tert-butylphosphinomethyl)pyridine)(CO)₂]; water; In tert-butyl alcohol; at 90 ℃; for 24h; Green chemistry;

DOI:10.1021/acscatal.1c01748

Reference yield: 91.0%

4-Methoxyphenylacetic acid (104-01-8) → 2-(4-methoxyphenyl)acetamide (6343-93-7)

Guidance literature:

With 1H-imidazole; urea; In octane; at 120 ℃; for 24h; Reagent/catalyst;

DOI:10.1039/d0sc01317j

Reference yield: 90.0%

4-Methoxyphenethylamine (55-81-2) → 2-(4-methoxyphenyl)acetamide (6343-93-7)

Guidance literature:

With C₃₁H₂₉Br₂N₃Ru; potassium tert-butylate; In tert-butyl alcohol; at 70 ℃; for 24h; regioselective reaction;

DOI:10.1039/d1cy01541a

upstream raw materials:

4-methoxy-phenyl acetic acid methyl ester

4-Methoxyphenylacetic acid

formamide

p-methoxybenzylnitrile

Downstream raw materials:

N-(Benzotriazol-1-yl-phenyl-methyl)-2-(4-methoxy-phenyl)-acetamide

6-(4-Chloro-phenyl)-3-(4-methoxy-phenyl)-4-phenyl-1H-pyridin-2-one

3-(4-Methoxy-phenyl)-4-pyridin-3-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one

4-methoxybenzylamine hydrochloride

Refernces

• 1、 Babón, Juan C.,Esteruelas, Miguel A.,López, Ana M.,O?ate, Enrique. "Hydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism". . p. 7284 - 7296. Retrieved 2021/05/29.
• 2、 Jung, Hui Jin,Nam, Eun Hye,Park, Jin Young,Ghosh, Prithwish,Kim, In Su. "Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor". . . Retrieved 2021/02/26.