2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE
• CAS No.: 6940-45-0
• Molecular Formula: C7H11N3O2
• Molecular Weight: 169.18
• Hs Code.: 2933599090
• Mol file: 6940-45-0.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-5-(2-hydroxyethyl)-6-methyl- (9CI);5-Pyrimidineethanol,2-amino-4-hydroxy-6-methyl- (7CI);NSC 60130;2-Amino-5-(2-hydroxyethyl)-6-methylpyrimidin-4-ol;2-Amino-5-(2-hydroxy-ethyl)-6-methyl-3H-pyrimidin-4-one;

Chemical Property of 2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 4.04E-06mmHg at 25°C
• Refractive Index: 1.636
• Boiling Point: 344.9 °C at 760 mmHg
• Flash Point: 162.4 °C
• PSA: 92.26000
• Density: 1.45 g/cm³
• LogP: 0.18880

Purity/Quality:

99.9% ^*data from raw suppliers

2-amino-5-(2-hydroxyethyl)-6-methylpyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE

There total 6 articles about 2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) + guanidine hydrochloride (50-01-1) → 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (6940-45-0)

Guidance literature:

With potassium carbonate; In neat (no solvent); at 140 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1039/c4ra00249k

Reference yield: 69.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (6940-45-0)

Guidance literature:

With triethylamine; In ethanol; for 5h; Heating;

DOI:10.1021/jm000200l

Reference yield:

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) → 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (6940-45-0)

Guidance literature:

triethylamine; In ethanol; water;

upstream raw materials:

3-acetyl-2-oxo-4,5-dihydrofuran

guanidine nitrate

guanidine carbonate

guanidine hydrogen carbonate

Downstream raw materials:

2-amino-5,6-dihydro-4-methylfuro[2,3-d]pyrimidine

diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl-7-(N-benzyl)]benzoyl}-L-glutamate

diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl-7-(N-benzyl)]benzoyl}-L-glutamate

diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl]benzoyl}-L-glutamate

Refernces

• 1、 -. "Fluorinated supramolecular polymers". . . Retrieved 2012/06/05.
• 2、 Gangjee,Yu,McGuire,Cody,Galitsky,Kisliuk,Queener. "Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent". . p. 3837 - 3851. Retrieved 2007/10/03.