4-Butoxybiphenyl

Base Information

• Chemical Name: 4-Butoxybiphenyl
• CAS No.: 6842-78-0
• Molecular Formula: C16H18O
• Molecular Weight: 226.318
• Hs Code.: 2909309090
• Mol file: 6842-78-0.mol

Synonyms:1, 1-Biphenyl, 4-butoxy-;1-Butoxy-4-phenyl-benzene;p-n-Butoxybiphenyl;Ether, 4-biphenylyl butyl;

Chemical Property of 4-Butoxybiphenyl

Chemical Property:

• Vapor Pressure: 0.000123mmHg at 25°C
• Melting Point: 70-72 °C
• Refractive Index: 1.538
• Boiling Point: 345.5 °C at 760 mmHg
• Flash Point: 137.2 °C
• PSA: 9.23000
• Density: 0.991 g/cm³
• LogP: 4.53250

Purity/Quality:

99% ^*data from raw suppliers

4-BUTOXY-1-PHENYLBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Butoxybiphenyl

There total 17 articles about 4-Butoxybiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-bromo-butane (109-65-9) + 4-Phenylphenol (92-69-3) → 4-butoxy-1,1’-biphenyl (6842-78-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 3.5h;

DOI:10.1080/00397919908086606

Reference yield: 92.0%

4-bromo-1,1'-biphenyl (92-66-0) + butan-1-ol (71-36-3) → 4-butoxy-1,1’-biphenyl (6842-78-0)

Guidance literature:

With copper(l) iodide; N¹, N²-diphenethyloxalamide; sodium t-butanolate; In 1,4-dioxane; for 24h; Schlenk technique; Inert atmosphere; Molecular sieve; Heating;

DOI:10.1021/jacs.8b12142

Reference yield: 87.0%

1-bromo-4-butoxybenzene (39969-57-8) + phenylboronic acid (98-80-6) → 4-butoxy-1,1’-biphenyl (6842-78-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 80 ℃; for 30h;

DOI:10.1039/b613522f

upstream raw materials:

1-bromo-butane

4-Phenylphenol

(4-Butoxy-phenyl)-piperidin-1-yl-diazene

benzene

Downstream raw materials:

biphenyl

C₄₈H₆₀O₅

C₄₆H₅₆O₅

C₄₂H₄₈O₅

Refernces

• 1、 Hara, Naofumi,Nakao, Yoshiaki,Saito, Teruhiko,Seki, Rin. "Selective C-O Bond Reduction and Borylation of Aryl Ethers Catalyzed by a Rhodium-Aluminum Heterobimetallic Complex". . p. 6388 - 6394. Retrieved 2021/05/31.
• 2、 Chen, Zhixiang,Jiang, Yongwen,Zhang, Li,Guo, Yinlong,Ma, Dawei. "Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction". supporting information. p. 3541 - 3549. Retrieved 2019/02/26.