N,N-dicyclohexylformamide

Base Information

• Chemical Name: N,N-dicyclohexylformamide
• CAS No.: 22699-63-4
• Molecular Formula: C13H23 N O
• Molecular Weight: 209.332
• Mol file: 22699-63-4.mol

Synonyms:N,N-Dicyclohexylformamide;NSC 406402

Chemical Property of N,N-dicyclohexylformamide

Chemical Property:

• Vapor Pressure: 2.41E-05mmHg at 25°C
• Boiling Point: 359.2°Cat760mmHg
• Flash Point: 162.8°C
• Density: 0.99g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dicyclohexylformamide

There total 19 articles about N,N-dicyclohexylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbon dioxide (124-38-9,18923-20-1) + N-cyclohexyl-cyclohexanamine (101-83-7) → N,N-dicyclohexylformamide (22699-63-4)

Guidance literature:

With 1,10-Phenanthroline; phenylsilane; zinc diacetate; In acetonitrile; at 25 ℃; for 8h; under 3750.38 Torr; Time; Autoclave;

DOI:10.1039/d0gc02890h

Reference yield: 90.0%

formic acid (64-18-6) + N-cyclohexyl-cyclohexanamine (101-83-7) → N,N-dicyclohexylformamide (22699-63-4)

Guidance literature:

With silica gel; for 0.015h; microwave irradiation;

DOI:10.1002/jccs.200700067

Reference yield: 82.0%

N1,N1,N2,N2-tetracyclohexylethane-1,2-diamine (3261-33-4) → N,N-dicyclohexylformamide (22699-63-4)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; water; oxygen; silica gel; caesium carbonate; In acetonitrile; at 20 ℃; for 60h; Inert atmosphere; Irradiation;

DOI:10.1016/j.tet.2013.07.056

upstream raw materials:

cyclohexanone

formamide

formic acid

N-cyclohexyl-cyclohexanamine

Downstream raw materials:

N,N-dicyclohexylcyanamide

N-(Chlormethylen)-N-cyclohexyl-cyclohexanaminium-chlorid

N,N-Dicyclohexyl-N-(diphenylmethyl)ammonium-fluorsulfonat

N,N-Dicyclohexyl-1-ethylpropylamin

Refernces

• 1、 Nudelman, N. Sbarbati,Perez, Daniel. "Insertion of Carbon Monoxide into Lithium-Nitrogen Bonds. One-Pot Synthesis of Dialkylformamides and Dialkylglyoxylamides". . p. 133 - 134. Retrieved 1983.
• 2、 Benaissa, Idir,Cantat, Thibault,Genre, Caroline,Godou, Timothé,Pinault, Mathieu. "Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst". . p. 57 - 61. Retrieved 2022/01/19.
• 3、 Sarkar, Debotra,Weetman, Catherine,Dutta, Sayan,Schubert, Emeric,Jandl, Christian,Koley, Debasis,Inoue, Shigeyoshi. "N-Heterocyclic Carbene-Stabilized Germa-acylium Ion: Reactivity and Utility in Catalytic CO2Functionalizations". supporting information. p. 15403 - 15411. Retrieved 2020/10/20.