NSC27893

Base Information

• Chemical Name: NSC27893
• CAS No.: 2412-58-0
• Molecular Formula: C10H11 N
• Molecular Weight: 145.204
• Hs Code.: 2933499090
• Mol file: 2412-58-0.mol

Synonyms:1-Methyl-3,4-dihydroisoquinoline;3,4-Dihydro-1-methylisoquinoline; NSC 27893

Chemical Property of NSC27893

Chemical Property:

• Vapor Pressure: 0.103mmHg at 25°C
• Melting Point: 189 °C
• Boiling Point: 229.8°Cat760mmHg
• PKA: 6.40±0.20(Predicted)
• Flash Point: 84.3°C
• PSA: 12.36000
• Density: 1.03g/cm³
• LogP: 1.48730
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

1-Methyl-3,4-dihydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NSC27893

There total 3 articles about NSC27893 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-methyl-1,2,3,4-tetrahydroisoquinoline (4965-09-7) → 1-methylisoquinoline (1721-93-3) + 1-methyl-3,4,dihydroisoquinoline (2412-58-0)

Guidance literature:

With sodium carbonate; In ethyl acetate; at 120 ℃; for 48h; Overall yield = 60 %; Sealed tube; Green chemistry;

DOI:10.1002/adsc.201700178

Reference yield:

→ 1-methyl-3,4,dihydroisoquinoline (2412-58-0) + methyl-N-(benzyl-methyl)-formamide (877-95-2)

Guidance literature:

With sulfur dioxide; phosphorus pentoxide; trichlorophosphate;

DOI:10.1246/bcsj.31.1003

Reference yield:

→ 1-methyl-3,4,dihydroisoquinoline (2412-58-0) + methyl-N-(benzyl-methyl)-formamide (877-95-2)

Guidance literature:

upstream raw materials:

1-methyl-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 Bahnemann, Detlef W.,Balayeva, Narmina O.,Dillert, Ralf,Mamiyev, Zamin,Zheng, Nan. "Rh/TiO2-Photocatalyzed Acceptorless Dehydrogenation of N-Heterocycles upon Visible-Light Illumination". . p. 5542 - 5553. Retrieved 2020/08/25.
• 2、 Zhang, Jingyu,Chen, Shiya,Chen, Fangfang,Xu, Wensheng,Deng, Guo-Jun,Gong, Hang. "Dehydrogenation of Nitrogen Heterocycles Using Graphene Oxide as a Versatile Metal-Free Catalyst under Air". supporting information. p. 2358 - 2363. Retrieved 2017/07/22.