10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide

Base Information

• Chemical Name: 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide
• CAS No.: 146-21-4
• Molecular Formula: C17H20 N2 O S
• Molecular Weight: 300.425
• Hs Code.: 2934300000
• Mol file: 146-21-4.mol

Synonyms:Phenothiazine,10-[3-(dimethylamino)propyl]-, 5-oxide (6CI,7CI,8CI); Promazine 5-oxide;Promazine S-oxide; Promazine sulfoxide; Propazin sulfoxide; Propazinesulfoxide; SKF 5418A

Chemical Property of 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide

Chemical Property:

• Melting Point: 114 - 116°C
• PSA: 42.76000
• LogP: 4.18720
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)

Purity/Quality:

99.90% ^*data from raw suppliers

Promazine Sulfoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Promazine Sulfoxide is a metabolite of Chlorpromazine (C424750) and an impurity of Promazine (P756300). Both Chlorpromazine and Promazine are antipsychotic drugs.

Technology Process of 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide

There total 7 articles about 10-[3-(Dimethylamino)propyl]-10H-phenothiazine 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

promazine Hydrochloride (53-60-1) → promazine sulfoxide (146-21-4)

Guidance literature:

promazine Hydrochloride; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃; Inert atmosphere;

With sodium hydroxide; In chloroform; water; Inert atmosphere;

DOI:10.3987/COM-16-13437

Reference yield: 15.0%

promazine (58-40-2) → 3H-Phenothiazin-3-one (581-30-6) + sulfoxyde de phenothiazine (1207-71-2) + promazine sulfoxide (146-21-4)

Guidance literature:

With bis(acetylacetonate)oxovanadium; iodoxybenzene; In benzene; for 4h; Product distribution; Heating;

Reference yield:

chlorpromazine radical cation (31755-50-7) → promazine (58-40-2) + promazine sulfoxide (146-21-4)

Guidance literature:

With water; In sulfuric acid; at 24.84 ℃; Concentration; pH-value; Kinetics;

DOI:10.1007/s11243-011-9531-x

upstream raw materials:

promazine Hydrochloride

promazine

promazine cation radical

chlorpromazine radical cation

Refernces

• 1、 Wojcikowski, Jacek,Pichard-Garcia, Lydiane,Maurel, Patrick,Daniel, Wladyslawa A.. "Contribution of human cytochrome P-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine". . p. 1465 - 1474. Retrieved 2003.
• 2、 Wisniewska, Joanna,Rzesnicki, Pawel,Topolski, Adrian. "A mechanistic study on the disproportionation and oxidative degradation of phenothiazine derivatives by manganese(III) complexes in phosphate acidic media". . p. 767 - 774. Retrieved 2012/07/01.