Dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride

Base Information

• Chemical Name: Dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride
• CAS No.: 53-60-1
• Molecular Formula: C17H20N2S.HCl
• Molecular Weight: 320.886
• Hs Code.: 2934302300
• Mol file: 53-60-1.mol

Synonyms:dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride;10H-Phenothiazine-10-propanamine, N,N-dimethyl-,monohydrochloride

Chemical Property of Dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride

Chemical Property:

• Vapor Pressure: 5.08E-07mmHg at 25°C
• Melting Point: 174-176 °C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 412.7 °C at 760 mmHg
• Flash Point: 203.4 °C
• PSA: 31.78000
• Density: 1.1435 (rough estimate)
• LogP: 5.10800
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 320.1113975
• Heavy Atom Count: 21
• Complexity: 285

Purity/Quality:

99% ^*data from raw suppliers

Promazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[NH+](C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31.[Cl-]
• Uses: Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells. Antipsychotic. Tranquilizer.
• Clinical Use: Antipsychotic for agitation and restlessness
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone. Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide, dronedarone and amiodarone - avoid with amiodarone and dronedarone. Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid. Antidepressants: increase concentrations and additive antimuscarinic effects, notably with tricyclics; increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine. Antiepileptics: antagonised (convulsive threshold lowered). Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone. Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid. Anxiolytics and hypnotics: increased sedative effects. Atomoxetine: increased risk of ventricular arrhythmias. Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol. Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide. Desferrioxamine: avoid concomitant use. Diuretics: enhanced hypotensive effect. Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity. Pentamidine: increased risk of ventricular arrhythmias. Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone, disopyramide and dronedarone. Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid. Antidepressants: increased level of tricyclics (possibly increased risk of ventricular arrhythmias and antimuscarinic side effects); increased risk of ventricular arrhythmias with citalopram and escitalopram - avoid; increased risk of convulsions with vortioxetine. Anticonvulsant: antagonises anticonvulsant effect. Antimalarials: avoid with artemether/lumefantrine and piperaquine with artenimol. Antipsychotics: increased risk of ventricular arrhythmias with droperidol and pimozide - avoid; increased risk of ventricular arrhythmias with risperidone. Antivirals: concentration possibly increased with ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid. Anxiolytics and hypnotics: increased sedative effects. Atomoxetine: increased risk of ventricular arrhythmias. Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol. Cytotoxics: increased risk of ventricular arrhythmias with arsenic trioxide. Diuretics: enhanced hypotensive effect. Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity. Pentamidine: increased risk of ventricular arrhythmias.

Technology Process of Dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride

There total 6 articles about Dimethyl(3-phenothiazin-10-ylpropyl)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

10H-phenothiazine (92-84-2) + 3-dimethylaminopropionic acid (6300-04-5) → promazine Hydrochloride (53-60-1)

Guidance literature:

3-dimethylaminopropionic acid; With sodium tetrahydroborate; In toluene; at 0 - 5 ℃;

10H-phenothiazine; With sodium tetrahydroborate; In toluene; at 25 - 75 ℃; for 4h;

With hydrogenchloride; In water; isopropyl alcohol;

DOI:10.1080/00397911.2017.1396613

Reference yield:

methanol (67-56-1) + chlorpromazine hydrochloride (69-09-0) → 2-methoxypromazine (61-01-8) + promazine Hydrochloride (53-60-1)

Guidance literature:

at 20 ℃; Quantum yield; Kinetics; Inert atmosphere; UV-irradiation;

DOI:10.1111/j.1751-1097.2008.00412.x

Reference yield:

propan-1-ol (71-23-8) + chlorpromazine hydrochloride (69-09-0) → 2-propoxypromazine (1156505-40-6) + promazine Hydrochloride (53-60-1)

Guidance literature:

at 20 ℃; Quantum yield; Kinetics; Inert atmosphere; UV-irradiation;

DOI:10.1111/j.1751-1097.2008.00412.x

upstream raw materials:

chlorpromazine hydrochloride

glycerol

methanol

propan-1-ol

Downstream raw materials:

promazine

Norpromazine

promazine sulfoxide

Refernces

• 1、 Quadri, Syed Aziz Imam,Das, Tonmoy C.,Jadhav, Shivaji,Farooqui, Mazahar. "Efficient synthesis of tertiary amine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) encat catalyst". supporting information. p. 267 - 277. Retrieved 2018/01/08.