1,1-Dichloro-2,2-difluoropropane

Base Information

• Chemical Name: 1,1-Dichloro-2,2-difluoropropane
• CAS No.: 1112-01-2
• Molecular Formula: C₃H₄Cl₂F₂
• Molecular Weight: 148.968
• Hs Code.: 2903791090
• DSSTox Substance ID: DTXSID501019255
• Nikkaji Number: J151.443A
• Mol file: 1112-01-2.mol

Synonyms:1,1-dichloro-2,2-difluoropropane;1112-01-2;HYDROCHLOROFLUOROCARBON-252 (HCFC-252);HCFC-252cb;SCHEMBL1994107;LEDXZTGCBJWOFY-UHFFFAOYSA-N;DTXSID501019255;MFCD20621731

Chemical Property of 1,1-Dichloro-2,2-difluoropropane

Chemical Property:

• Refractive Index: 1.3633 (estimate)
• Boiling Point: 44.18°C (rough estimate)
• PSA: 0.00000
• Density: 1.5635 (estimate)
• LogP: 2.44530
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 147.9658118
• Heavy Atom Count: 7
• Complexity: 62

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1-Dichloro-2,2-difluoropropane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(Cl)Cl)(F)F

Technology Process of 1,1-Dichloro-2,2-difluoropropane

There total 5 articles about 1,1-Dichloro-2,2-difluoropropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1,1,3,3-tetrachloro-1,2,2-trifluoropropane (422-52-6,134237-37-9) → 1,1-dichloro-2,2-difluoropropane (1112-01-2) + 1,1-dichloro-1,2,2-trifluoropropane (7125-99-7) + 1,1,3-trichloro-1,2,2-trifluoropropane (421-99-8) + 1,1,3-trichloro-2,2,3-trifluoropropane (131221-36-8)

Guidance literature:

With hydrogen; platinum on activated charcoal; at 120 ℃; Further byproducts given;

DOI:10.1016/S0022-1139(00)82839-0

Reference yield:

2,2-difluoropropane (420-45-1) → 1,1-dichloro-2,2-difluoropropane (1112-01-2)

Guidance literature:

With water; chlorine; at 60 - 70 ℃; im Licht;

DOI:10.1021/ja01869a019 DOI:10.1021/ja01290a097

Reference yield:

diethyl ether (60-29-7,927820-24-4) + 1,1'-dichloro-2,2'-difluoroethene (79-35-6) → 1,1-dichloro-2,2-difluoropropane (1112-01-2) + 1,1-dichloro-2-fluoro-propene (430-95-5) + 1,1-dichloro-3-ethoxy-2,2-difluoro-butane (2358-01-2) + 1,1-dichloro-3-ethoxy-2-fluoro-but-1-ene (16685-91-9)

Guidance literature:

With methylmagnesium bromide; for 58h; Yield given. Yields of byproduct given; Heating; further alkyl Grignard reagents;

DOI:10.1021/ja00521a038

upstream raw materials:

2,2-difluoropropane

diethyl ether

1,1'-dichloro-2,2'-difluoroethene

methylmagnesium bromide

Downstream raw materials:

1,1,1,3,3,3-hexachloro-2,2-difluoro-propane

Refernces

• 1、 Tanuma, T.,Ohnishi, K.,Okamoto, H.,Miyajima, T.,Morikawa, S.. "19F nuclear magnetic resonance studies of halogenated propanes". . p. 259 - 284. Retrieved 2007/10/02.