4-(2-Methoxyethyl)aniline

Base Information

• Chemical Name: 4-(2-Methoxyethyl)aniline
• CAS No.: 84803-56-5
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922199090
• European Community (EC) Number: 284-182-9
• DSSTox Substance ID: DTXSID90233845
• Nikkaji Number: J309.455C
• Wikidata: Q83115511
• Mol file: 84803-56-5.mol

Synonyms:4-(2-Methoxyethyl)aniline;84803-56-5;EINECS 284-182-9;4-(2-Methoxyethyl)benzenamine;4-(2-methoxy-ethyl)-phenylamine;4-methoxyethylaniline;SCHEMBL5659;DTXSID90233845;LGBFKALRQPQBJJ-UHFFFAOYSA-N;[4-(2-methoxy ethyl)phenyl]amine;AKOS000145900;SB76179;CS-0251153;FT-0671077;EN300-53778;F11764

Chemical Property of 4-(2-Methoxyethyl)aniline

Chemical Property:

• Vapor Pressure: 0.0342mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 242.3 °C at 760 mmHg
• Flash Point: 100.9 °C
• PSA: 35.25000
• Density: 1.025 g/cm³
• LogP: 2.03890
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Methoxyethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCC1=CC=C(C=C1)N
• Uses: 4-(2-methoxyethyl)aniline is used in the synthesis of selective β-adrenergic blocker Metoprolol 4-(2-methoxyethyl)aniline is used in the synthesis of selective β-adrenergic blocker labelled Metoprolol Used in the synthesis of selective β-adrenergic blocker Metoprolol.

Technology Process of 4-(2-Methoxyethyl)aniline

There total 9 articles about 4-(2-Methoxyethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(2-methoxyethenyl)-4-nitrobenzene (66821-15-6,66821-16-7,59436-14-5) → 4-(2-methoxyethyl)aniline (84803-56-5)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In ethyl acetate; at 50 ℃; under 37503.8 Torr;

DOI:10.1016/j.tetlet.2016.03.037

Reference yield: 71.4%

p-bromo-β-methoxyethylbenzene (60835-90-7) → 4-(2-methoxyethyl)aniline (84803-56-5)

Guidance literature:

With ammonium hydroxide; copper(l) iodide; caesium carbonate; acetylacetone; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Sealed tube;

Reference yield:

2-(4-nitrophenyl)ethyl methyl ether (69628-98-4) → 4-(2-methoxyethyl)aniline (84803-56-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; under 760.051 Torr;

upstream raw materials:

methoxyethene

para-nitrophenyl bromide

2-(4-nitrophenyl)ethyl methyl ether

2-(4-bromophenyl)-acetic acid

Downstream raw materials:

4-(3-chlorophenyl)-6-ethyl-N-(4-(2-methoxyethyl)phenyl)-1,3,5-triazin-2-amine

2-chloro-4-(2-methoxy-ethyl)-phenylamine

N-[4-(2-methoxy-ethyl)-phenyl]-acetamide

4-(2-methoxyethyl)phenol

Refernces

• 1、 -. "OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS". . . Retrieved 2015/05/19.
• 2、 -. "HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH". Page 62. . Retrieved 2010/02/09.